The Early Genes c-fos and c-jun: Potential Targets to Modulate Estrogen Action in Endometriosis?

Fernando M. Reis, Débora Martinho Morsch, Ana Luiza Lunardi Rocha, Márcia Mendonça Carneiro, Poli Mara Spritzer
In: Journal of Endometriosis · 2009 · vol. 1(1) , pp. 30–35 · doi:10.1177/228402650900100105 · W4237122051
OA: closed CC0 ⤵ 2 in-corpus citations
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C-fos and c-jun gene expression are increased in endometriotic implants compared to normal endometrium, suggesting they may be involved in estrogen-dependent proliferation and potential therapeutic targets.

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Abstract

Endometriosis is a common estrogen-dependent disorder. C-fos and c-jun are early transcription factors probably related to estradiol-dependent cell proliferation. C-fos gene expression is higher in endometriotic implants compared to normal endometrium and the distribution of c-Fos protein is higher in the stroma of endometriotic tissue. C-Jun expression is also more abundant in ectopic endometrial tissue. These findings point to an increased estrogen signaling in endometriosis and suggest that c-fos and c-jun could be potential targets to emerging treatments designed to affect selectively the endometriotic tissue, such as tissue-specific gene therapy.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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