Endostatin gene therapy for endometriosis in rats

T T Zhang, Zhang TT, X L Fang, Fang XL, Julie Gang, Gang J, J Gang
The Journal of international medical research · 2012 · vol. 40(5) , pp. 1840–1849 · doi:10.1177/030006051204000522 · PMID:23206465 · W2144854739
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Endostatin gene therapy in rats reduced endometriotic lesion size and serum VEGF by increasing lesion endostatin expression and decreasing MVD and MMP-2.

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Abstract

OBJECTIVE: Endostatin gene therapy for endometriosis was studied in an experimental autotransplantation model in rats. METHODS: Endometriotic lesions were transfected by intralesional injection of the plasmid lipofectamine-endostatin-pBud (group 1), lipofectamine-pBud (empty vector; group 2) or phosphate-buffered saline (group 3). Endostatin mRNA and protein levels in lesions were evaluated by quantitative real-time reverse transcription-polymerase chain reaction and Western blot analysis. Endostatin and vascular endothelial growth factor (VEGF) protein levels in serum, and microvessel density (MVD) and matrix metalloproteinase (MMP)-2 protein levels in endometriotic lesions, were also determined. RESULTS: Lipofectamine-endostatin-pBud injection increased endostatin mRNA and protein levels in lesions. Lesions were significantly smaller, and serum VEGF levels significantly lower, in group 1 versus controls. Serum VEGF was significantly and negatively correlated with serum endostatin. In group 1, MMP-2 levels and MVD were significantly lower versus controls. MMP-2 level was negatively correlated with endostatin. CONCLUSIONS: Gene therapy with endostatin appears to be an effective treatment for endometriosis. Restoration of endostatin gene expression by gene transfer in vivo might be a potential gene therapy approach for human endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inhibitors Endometriosis Endostatins Genetic Therapy Genetic Therapy Angiogenesis Inhibitors Angiogenesis Inhibitors Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Animals Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endometrium Endostatins

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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