In situ methotrexate injection for treatment of recurrent endometriotic cysts

Agostini A, Aubert Agostini, Thomas De Lapparent, De Lapparent T, Emmanuelle Collette, Collette E, Capelle M, Mariane Capelle, Cravello L, L. Cravello, Ludovic Cravello, Blanc B, Bernard Blanc
European journal of obstetrics, gynecology, and reproductive biology · 2006 · vol. 130(1) , pp. 129–131 · doi:10.1016/j.ejogrb.2006.01.015 · PMID:16530317 · W2020142648
Non-randomised trial OA: closed CC0 ⤵ 32 in-corpus citations
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This study investigated the efficacy of in situ methotrexate injections as a treatment for recurrent endometriotic cysts.

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Abstract

OBJECTIVE: Ovarian endometrioma recurrence is frequent. Conventional treatment of ovarian endometrioma is by surgical cystectomy. We proposed an alternative medical treatment for recurrent ovarian endometrioma: cyst aspiration followed by in situ methotrexate injection. STUDY DESIGN: From January 2002 to May 2003, 14 patients with recurrent homolateral ovarian endometrioma underwent transvaginal ultrasound guided cyst puncture and aspiration followed by methotrexate injection, whilst under general anasthesia. Recurrence rate during follow up was evaluated. RESULTS: No complication was reported. After a mean follow up of 20+/-5 month (min: 13, max: 29), four recurrences were diagnosed (28.6%). Two asymptomatic recurrences were not treated and two painful recurrences underwent a second cyst drainage with methotrexate injection. CONCLUSIONS: In situ methotrexate injection is a simple, effective and an interesting alternative to surgical treatment in women with recurrent homolateral ovarian endometrioma.

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Condition tags

endometriosis

MeSH descriptors

Antimetabolites, Antineoplastic Endometriosis Methotrexate Ovarian Cysts Adult Adult Antimetabolites, Antineoplastic Antimetabolites, Antineoplastic Endometriosis Endometriosis Endometriosis Female Female Humans Humans Injections, Intralesional Injections, Intralesional Methotrexate Methotrexate Middle Aged

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (15)

Cited by (32)

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europepmc
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License: CC0 · commercial use OK