The Effectiveness of Phalleria macrocarpa Bioactive Fraction in Alleviating Endometriosis and/or Adenomyosis Related Pain

Budi Wiweko, Caroline G. Puspita, Raymond R. Tjandrawinata, Herbert Situmorang, Herbert Sıtumorang, Achmad Kemal Harzif, Gita Pratama, Kanadi Sumapraja, Muharam Natadisastra, Raden Muharam, Andon Hestiantoro
In: eJournal Kedokteran Indonesia · 2015 · vol. 3(1) · doi:10.23886/ejki.3.4824. · W2225920452
Non-randomised trial OA: diamond CC0 ⤵ 2 in-corpus citations
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A pilot study found that the bioactive extract DLBS1442 effectively reduced endometriosis- and/or adenomyosis-related pain, as measured by the visual analog scale.

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Abstract

The overexpression of estrogen receptor-beta (ER-s) and the cyclooxygenase-2 (COX-2) enzyme coupled with the absence of expression of progesterone receptors (PR) is critical to thepathogenesis of endometriosis and adenomyosis associated pain.n DLBS1442, a novel bioactiveextract of Phaleria macrocarpa, exerts its action by downregulating the overexpressed ER-s andCOX-2 products and up-regulating PR gene expression. This pilot study was conducted to evaluatethe effectiveness of DLBS1442 treatment in alleviating endometriosis- and/or adenomyosis-relatedpain. Ten endometriosis and/or adenomyosis patients were recruited consecutively at YasminClinic Dr. Cipto Mangunkusumo General Hospital in January - March 2013. Pain associated withmenses, including pre-menstrual pain, dysmenorrhea, dyschezia and dysuria, was measuredusing the visual analog scale (VAS) at each of the next three menstrual cycles. Patients reportingone or more pain symptoms with a VAS score = 4 were given 100 mg of DLBS1442 three timesdaily for 12 weeks. VAS score reduction was noted in the first post-treatment menstrual cycle(approximately 5.3 weeks after treatment initiation) and VAS scores continued to decline overthe final two cycles. DLBS1442 was effective in alleviating endometriosis- and/ or adenomyosisrelatedpain, as demonstrated by early pain reduction as evaluated using the VAS.

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Outcome instruments

VAS-pain

Condition tags

endometriosisadenomyosisdysmenorrhea

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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