Office gel sonovaginography for the prediction of posterior deep infiltrating endometriosis: a multicenter prospective observational study

S Reid, C Lu, Chuan Lü, N Hardy, Nigel Hardy, I Casikar, Gavin E. Reid, G Reid, G Cario, Danny Chou, D Chou, D Almashat, G Condous
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2014 · vol. 44(6) , pp. 710–718 · doi:10.1002/uog.13422 · PMID:24862965 · W2078418784
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Office gel sonovaginography accurately predicts posterior deep infiltrating endometriosis, especially bowel DIE, with high specificity and negative predictive value for vaginal and rectovaginal septum DIE.

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Abstract

OBJECTIVE: To use office gel sonovaginography (SVG) to predict posterior deep infiltrating endometriosis (DIE) in women undergoing laparoscopy. METHODS: This was a multicenter prospective observational study carried out between January 2009 and February 2013. All women were of reproductive age, had a history of chronic pelvic pain and underwent office gel SVG assessment for the prediction of posterior compartment DIE prior to laparoscopic endometriosis surgery. Gel SVG findings were compared with laparoscopic findings to determine the diagnostic accuracy of office gel SVG for the prediction of posterior compartment DIE. RESULTS: In total, 189 women underwent preoperative gel SVG and laparoscopy for endometriosis. At laparoscopy, 57 (30%) women had posterior DIE and 43 (23%) had rectosigmoid/anterior rectal DIE. For the prediction of rectosigmoid/anterior rectal (i.e. bowel) DIE, gel SVG had an accuracy of 92%, sensitivity of 88%, specificity of 93%, positive predictive value (PPV) of 79%, negative predictive value (NPV) of 97%, positive likelihood ratio (LR+) of 12.9 and negative likelihood ratio (LR-) of 0.12 (P = 3.98E-25); for posterior vaginal wall and rectovaginal septum (RVS) DIE, respectively, the accuracy was 95% and 95%, sensitivity was 18% and 18%, specificity was 99% and 100%, PPV was 67% and 100%, NPV was 95% and 95%, LR+ was 32.4 and infinity and LR- was 0.82 and 0.82 (P = 0.009 and P = 0.003). CONCLUSIONS: Office gel SVG appears to be an effective outpatient imaging technique for the prediction of bowel DIE, with a higher accuracy for the prediction of rectosigmoid compared with anterior rectal DIE. Although the sensitivity for vaginal and RVS DIE was limited, gel SVG had a high specificity and NPV for all forms of posterior DIE, indicating that a negative gel SVG examination is highly suggestive of the absence of DIE at laparoscopy.

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Condition tags

endometriosisdie_deep_infiltratingchronic_pelvic_pain

MeSH descriptors

Endometriosis Rectal Diseases Sigmoid Diseases Vagina Adult Endometriosis Endometriosis Female Humans Laparoscopy Predictive Value of Tests Prospective Studies Rectal Diseases Rectal Diseases Sensitivity and Specificity Sigmoid Diseases Sigmoid Diseases Ultrasonography Vagina

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