Tumor markers and neutrophil-lymphocyte ratio’s predictive role in endometriosis

Ayhan ATIGAN, Tolga Güler
In: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi · 2020 · vol. 15(2) , pp. 20–23 · doi:10.17517/ksutfd.607197 · W3034070397
OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-03 ⓘ

This study investigated the diagnostic value of neutrophil-lymphocyte ratio and CA-125 for endometriosis, finding both markers were increased in affected patients.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-29 · read from full text ⓘ

This retrospective study analyzed medical records from 30 patients who underwent surgery for endometriosis to evaluate the diagnostic utility of neutrophil-lymphocyte ratio and CA-125 levels. The researchers found that both markers were elevated in the patient cohort compared to expected baselines, supporting their potential as non-invasive diagnostic indicators. The authors note that establishing such a blood-based test could reduce surgical risks and improve treatment accessibility by avoiding unnecessary laparoscopy. This paper is centrally about endometriosis — specifically investigating serum biomarkers for its diagnosis without surgical confirmation.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objective: Endometriosis is characterized by the development of endometrial tissue outside the uterine cavity. Aim of this study is to investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR) and cancer antigen (CA)-125 in a diagnosis of endometriosis. Material and methods: In this retrospective study, the medical data of a total of 30 patients who underwent surgery due to endometriosis between January 2012 to December 2017 at Pamukkale University were analyzed. Results: NLR and CA-125 were increased in the patients with endometriosis. Conclusion: A diagnostic test without the need for surgery will reduce the associated surgical risks, increase accessibility to a diagnostic test and improve treatment outcomes.
Full text 2,332 characters · extracted from oa-doi-fallback · 5 sections · click to expand

Abstract

Objective: Endometriosis is characterized by the development of endometrial tissue outside the uterine cavity. Aim of this study is to investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR) and cancer antigen (CA)-125 in a diagnosis of endometriosis.

Material and methods

In this retrospective study, the medical data of a total of 30 patients who underwent surgery due to endometriosis between January 2012 to December 2017 at Pamukkale University were analyzed.

Results

NLR and CA-125 were increased in the patients with endometriosis.

Conclusion

A diagnostic test without the need for surgery will reduce the associated surgical risks, increase accessibility to a diagnostic test and improve treatment outcomes.

Keywords

References - 1. Giudice LC, Kao LC. Endometriosis. Lancet 2004;364:1789-99. - 2. Giudice LC, Clinical practice Endometriosis. N. Engl. J. Med. 2010;362:2389–98. - 3. Mounsey AL, Wilgus A, Slawson DC. Diagnosis and management of endometriosis. American Family Physician. 2006;74:594–600. - 4. Wellbery C. Diagnosis and treatment of endometriosis. American Family Physician. 1999; 60:1753–62. - 5. Barbieri RL, Niloff JM, Bast Jr. RC, Scaetzl E, Kistner RW, Knapp RC. Elevated serum concentrations of CA-125 in patients with advanced endometriosis. Fertil Steril 1986;45:630–4. - 6. May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update 2010;16: 651–74. - 7. Kajihara H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S et al. New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal. Gynecol Endocrinol 2011;27:73–9. - 8. Viganò P, Parazzini F, Somigliana E, Vercellini P. Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol. 2004;18:177–200. - 9. Yang H, Lang JH, Zhu L, Wang S, Sha GH, Zhang Y. Diagnostic value of the neutrophil-to-lymphocyte ratio and the combination of serum CA-125 for stages III and IV endometriosis. Chin Med J 2013;126:2011-14. - 10. Tazegül A, Acar A. Klinigimizde Gerceklestirilen Histerektomi Olgularının Klinik ve Demografik Ozelliklerinin Degerlendirilmesi. Selçuk Tıp Derg 2010;26:19-22.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK