{"paper_id":"ba523cf6-9545-4e5b-aec6-27d912f61ed9","body_text":"Tumor markers and neutrophil-lymphocyte ratio’s predictive role in endometriosis\nAbstract\nObjective: Endometriosis is characterized by the development of endometrial tissue outside the uterine cavity. Aim of this study is to investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR) and cancer antigen (CA)-125 in a diagnosis of endometriosis.\nMaterial and methods: In this retrospective study, the medical data of a total of 30 patients who underwent surgery due to endometriosis between January 2012 to December 2017 at Pamukkale University were analyzed.\nResults: NLR and CA-125 were increased in the patients with endometriosis.\nConclusion: A diagnostic test without the need for surgery will reduce the associated surgical risks, increase accessibility to a diagnostic test and improve treatment outcomes.\nKeywords\nReferences\n- 1. Giudice LC, Kao LC. Endometriosis. Lancet 2004;364:1789-99.\n- 2. Giudice LC, Clinical practice Endometriosis. N. Engl. J. Med. 2010;362:2389–98.\n- 3. Mounsey AL, Wilgus A, Slawson DC. Diagnosis and management of endometriosis. American Family Physician. 2006;74:594–600.\n- 4. Wellbery C. Diagnosis and treatment of endometriosis. American Family Physician. 1999; 60:1753–62.\n- 5. Barbieri RL, Niloff JM, Bast Jr. RC, Scaetzl E, Kistner RW, Knapp RC. Elevated serum concentrations of CA-125 in patients with advanced endometriosis. Fertil Steril 1986;45:630–4.\n- 6. May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update 2010;16: 651–74.\n- 7. Kajihara H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S et al. New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal. Gynecol Endocrinol 2011;27:73–9.\n- 8. Viganò P, Parazzini F, Somigliana E, Vercellini P. Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol. 2004;18:177–200.\n- 9. Yang H, Lang JH, Zhu L, Wang S, Sha GH, Zhang Y. Diagnostic value of the neutrophil-to-lymphocyte ratio and the combination of serum CA-125 for stages III and IV endometriosis. Chin Med J 2013;126:2011-14.\n- 10. Tazegül A, Acar A. Klinigimizde Gerceklestirilen Histerektomi Olgularının Klinik ve Demografik Ozelliklerinin Degerlendirilmesi. Selçuk Tıp Derg 2010;26:19-22.","source_license":"CC0","license_restricted":false}