Tumor markers and neutrophil-lymphocyte ratio’s predictive role in endometriosis

Ayhan ATIGAN, Tolga Güler
In: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi · 2020 · vol. 15(2) , pp. 20–23 · doi:10.17517/ksutfd.607197 · W3034070397
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This study investigated the diagnostic value of neutrophil-lymphocyte ratio and CA-125 for endometriosis, finding both markers were increased in affected patients.

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This retrospective study analyzed medical records from 30 patients who underwent surgery for endometriosis to evaluate the diagnostic utility of neutrophil-lymphocyte ratio and CA-125 levels. The researchers found that both markers were elevated in the patient cohort compared to expected baselines, supporting their potential as non-invasive diagnostic indicators. The authors note that establishing such a blood-based test could reduce surgical risks and improve treatment accessibility by avoiding unnecessary laparoscopy. This paper is centrally about endometriosis — specifically investigating serum biomarkers for its diagnosis without surgical confirmation.

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Abstract

Objective: Endometriosis is characterized by the development of endometrial tissue outside the uterine cavity. Aim of this study is to investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR) and cancer antigen (CA)-125 in a diagnosis of endometriosis. Material and methods: In this retrospective study, the medical data of a total of 30 patients who underwent surgery due to endometriosis between January 2012 to December 2017 at Pamukkale University were analyzed. Results: NLR and CA-125 were increased in the patients with endometriosis. Conclusion: A diagnostic test without the need for surgery will reduce the associated surgical risks, increase accessibility to a diagnostic test and improve treatment outcomes.
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Abstract

Objective: Endometriosis is characterized by the development of endometrial tissue outside the uterine cavity. Aim of this study is to investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR) and cancer antigen (CA)-125 in a diagnosis of endometriosis.

Material and methods

In this retrospective study, the medical data of a total of 30 patients who underwent surgery due to endometriosis between January 2012 to December 2017 at Pamukkale University were analyzed.

Results

NLR and CA-125 were increased in the patients with endometriosis.

Conclusion

A diagnostic test without the need for surgery will reduce the associated surgical risks, increase accessibility to a diagnostic test and improve treatment outcomes.

Keywords

References - 1. Giudice LC, Kao LC. Endometriosis. Lancet 2004;364:1789-99. - 2. Giudice LC, Clinical practice Endometriosis. N. Engl. J. Med. 2010;362:2389–98. - 3. Mounsey AL, Wilgus A, Slawson DC. Diagnosis and management of endometriosis. American Family Physician. 2006;74:594–600. - 4. Wellbery C. Diagnosis and treatment of endometriosis. American Family Physician. 1999; 60:1753–62. - 5. Barbieri RL, Niloff JM, Bast Jr. RC, Scaetzl E, Kistner RW, Knapp RC. Elevated serum concentrations of CA-125 in patients with advanced endometriosis. Fertil Steril 1986;45:630–4. - 6. May KE, Conduit-Hulbert SA, Villar J, Kirtley S, Kennedy SH, Becker CM. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update 2010;16: 651–74. - 7. Kajihara H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S et al. New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal. Gynecol Endocrinol 2011;27:73–9. - 8. Viganò P, Parazzini F, Somigliana E, Vercellini P. Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol. 2004;18:177–200. - 9. Yang H, Lang JH, Zhu L, Wang S, Sha GH, Zhang Y. Diagnostic value of the neutrophil-to-lymphocyte ratio and the combination of serum CA-125 for stages III and IV endometriosis. Chin Med J 2013;126:2011-14. - 10. Tazegül A, Acar A. Klinigimizde Gerceklestirilen Histerektomi Olgularının Klinik ve Demografik Ozelliklerinin Degerlendirilmesi. Selçuk Tıp Derg 2010;26:19-22.

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Condition tags

endometriosis

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