Effect of Letrozole on endometriosis-related pelvic pain.

Fariba Almassinokiani, Alireza Almasi, Peyman Akbari, Mahboubeh Saberifard
Medical journal of the Islamic Republic of Iran · 2014 · vol. 28 , pp. 107 · PMID:25664308 · W2187442345
article OA: green CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This trial compared letrozole plus OCP to OCP alone for endometriosis pain, finding both treatments equally effective after four months.

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Abstract

BACKGROUND: To determine the role of Letrozole, an aromatase inhibitor, in the treatment of endometriotic pain. METHODS: In this prospective, randomized, controlled clinical trial in minimally invasive surgery research center, 51 women with pelvic endometriosis and endometriotic pain (dyspareunia, dysmenorrhea, pelvic pain) score of 5 or more (for at least one of these endometriotic pain), after laparoscopic diagnosis and conservative laparoscopic surgery were treated with either Letrozole plus OCP (n=25) or only OCP (n=26) for 4 months continuously. RESULTS: Using VAS test, the score of dyspareunia, dysmenorrhea and pelvic pain 4 months after the laparoscopic surgery declined significantly in both groups but the difference between results of the two groups was not significant. CONCLUSION: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis and in comparison with OCP, Letrozole did not affect the outcome.

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Outcome instruments

VAS-pain

Condition tags

endometriosisdysmenorrheadyspareunia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (7)

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