Endometrioid Adenocarcinoma Arising from Colonic Endometriosis Mimicking Primary Colonic Carcinoma

Chen KT, Karl T. K. Chen
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2002 · vol. 21(3) , pp. 285–288 · doi:10.1097/00004347-200207000-00014 · PMID:12068177 · W2035203837
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This case report details an endometrioid adenocarcinoma originating in colonic endometriosis, which presented with features indistinguishable from primary colonic carcinoma, and outlines diagnostic criteria differentiating it.

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This case report describes a rare instance of endometrioid adenocarcinoma developing within colonic endometriosis, which clinically and histologically resembled primary colon cancer. The authors highlight specific differential diagnostic features that allowed for the correct identification of the tumor, including associated endometriosis, focal squamous differentiation, low nuclear grade, and a distinct immunophenotype characterized by CK7 positivity and CK20 negativity. These findings emphasize the importance of recognizing this malignancy to avoid misdiagnosis as a primary gastrointestinal carcinoma. This paper is centrally about endometriosis — specifically the malignant transformation of deep infiltrating endometriosis in the colon into endometrioid adenocarcinoma.

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Abstract

The clinicopathologic features of a case of endometrioid adenocarcinoma arising from colonic endometriosis that clinically and histologically mimicked a primary colonic carcinoma are reported. The differential diagnostic features of the tumor leading to the correct diagnosis included associated endometriosis, a minor mucosal component, focal squamous differentiation, absence of dirty necrosis, low nuclear grade, absence of a colonic adenoma, and a CK7+/CK20-/CEA- immunophenotype.
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CASE REPORTS Endometrioid Adenocarcinoma Arising from Colonic Endometriosis Mimicking Primary Colonic Carcinoma - Karl T. K. Chen International Journal of Gynecological Pathology 21(3):p 285-288, July 2002. Summary: The clinicopathologic features of a case of endometrioid adenocarcinoma arising from colonic endometriosis that clinically and histologically mimicked a primary colonic carcinoma are reported. The differential diagnostic features of the tumor leading to the correct diagnosis included associated endometriosis, a minor mucosal component, focal squamous differentiation, absence of dirty necrosis, low nuclear grade, absence of a colonic adenoma, and a CK7+/CK20−/CEA− immunophenotype. Copyright ©2002International Society of Gynecological Pathologists

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Carcinoma, Endometrioid Colonic Diseases Colonic Diseases Colonic Neoplasms Colonic Neoplasms Endometriosis Endometriosis Adenocarcinoma Adenocarcinoma Aged Aged, 80 and over Carcinoembryonic Antigen Carcinoembryonic Antigen Carcinoma, Endometrioid Carcinoma, Endometrioid Colonic Diseases Colonic Diseases Colonic Neoplasms Colonic Neoplasms

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