Analysis of gene expression and activation of signalling pathways in eutopic and ectopic endometrium of patients with external genital endometriosis

L.V. Adamyan, А. А. Осипова, Ya. B. Aznaurova, М. М. Сонова, I.V. Petrov, Maria Suntsova, A. A. Buzdin
In: Voprosy ginekologii, akušerstva i perinatologii · 2019 · vol. 18(1) , pp. 6–10 · doi:10.20953/1726-1678-2019-1-6-10 · W2936273242
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This study analyzed gene expression and signaling pathways in eutopic and ectopic endometrium from patients with endometriosis, finding similarities that suggest eutopic endometrium transcriptome could mark endometriosis presence.

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This study performed transcriptome analysis on endometrial tissue from 12 patients with external genital endometriosis, comparing eutopic versus ectopic endometrium, and contrasted these findings with eutopic endometrium from 7 women without endometriosis (excluding inflammatory pelvic disease, endometrial hyperplasia, uterine myoma, adenomyosis, and recent hormonal therapy or intrauterine system use). The authors identified differentially expressed genes in endometrial specimens in the presence or absence of endometriosis and reported differentially activated signaling pathways between eutopic and ectopic endometrium in patients with endometriosis. A key limitation is the small sample size and that tissue sourcing and exclusion criteria constrain generalizability. This paper is centrally about endometriosis — it analyzes gene expression and signaling pathway activation in eutopic and ectopic endometrium from patients with external genital endometriosis.

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Gynecology, Obstetrics and Perinatology - Gynecology, Obstetrics and Perinatology - 2019 volume 18 issue 1 Analysis of gene expression and activation of signalling pathways in eutopic and ectopic endometrium of patients with external genital endometriosis Authors / Institutions L.V.Adamyan / А.А.Оsipova / Ya.B.Aznaurova / M.M.Sonova / I.V.Petrov / M.V.Suntsova / А.А.Buzdin / The objective. Transcriptome analysis of specimens of eutopic and ectopic endometrium of patients with endometriosis and specimens of eutopic endometrium of women without this disease. Patients and methods. The study included 12 patients with external genital endometriosis and 7 patients with a deficient uterine scar after caesarean section. Criteria of exclusion were inflammatory diseases of the pelvic organs; endometrial hyperplasia, uterine myoma, adenomyosis, the use of hormonal therapy or an intrauterine system for one year before operative treatment. Results. Differentially expressed genes were found in the endometrial specimens of patients with endometriosis or without it, and also differentially activated signalling pathways in specimens of eutopic and ectopic endometrium taken from patients with endometriosis. Conclusions. The data we have obtained are indicative of a considerable similarity of specimens of eutopic and ectopic endometrium of patients with endometriosis, which presupposes a possibility of using the transcriptome of the eutopic endometrium as a marker of the presence of foci of endometriosis. Key words: biomarkers, diagnostics, transcriptome, eutopic endometrium, endometriosis. For citation: Adamyan L.V., Оsipova А.А., Aznaurova Ya.B., Sonova M.M., Petrov I.V., Suntsova M.V., Buzdin А.А. Analysis of gene expression and activation of signalling pathways in eutopic and ectopic endometrium of patients with external genital endometriosis. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2019; 18(1): 6–10. (In Russian). DOI: 10.20953/1726-1678-2019-1-6-10 Patients and methods. The study included 12 patients with external genital endometriosis and 7 patients with a deficient uterine scar after caesarean section. Criteria of exclusion were inflammatory diseases of the pelvic organs; endometrial hyperplasia, uterine myoma, adenomyosis, the use of hormonal therapy or an intrauterine system for one year before operative treatment. Results. Differentially expressed genes were found in the endometrial specimens of patients with endometriosis or without it, and also differentially activated signalling pathways in specimens of eutopic and ectopic endometrium taken from patients with endometriosis. Conclusions. The data we have obtained are indicative of a considerable similarity of specimens of eutopic and ectopic endometrium of patients with endometriosis, which presupposes a possibility of using the transcriptome of the eutopic endometrium as a marker of the presence of foci of endometriosis. Key words: biomarkers, diagnostics, transcriptome, eutopic endometrium, endometriosis. For citation: Adamyan L.V., Оsipova А.А., Aznaurova Ya.B., Sonova M.M., Petrov I.V., Suntsova M.V., Buzdin А.А. Analysis of gene expression and activation of signalling pathways in eutopic and ectopic endometrium of patients with external genital endometriosis. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2019; 18(1): 6–10. (In Russian). DOI: 10.20953/1726-1678-2019-1-6-10

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