Impact of haemostatic sealant versus electrocoagulation on ovarian reserve after laparoscopic ovarian cystectomy of ovarian endometriomas: a randomised controlled trial

Jacqueline Pui Wah Chung, TSM Law, Chs Chung, Jennifer Sze Man Mak, D S Sahota, Daljit Singh Sahota, T. C. Li, Tin Chiu Li
BJOG: An International Journal of Obstetrics & Gynaecology · 2019 · vol. 126(10) , pp. 1267–1275 · doi:10.1111/1471-0528.15807 · PMID:31038276 · W2943590688
RCT OA: bronze CC0 ⤵ 20 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-13 ⓘ

Laparoscopic cystectomy for ovarian endometriomas using haemostatic sealant resulted in a greater increase in antral follicle count at 3 months compared to bipolar coagulation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate the effect of haemostatic sealant compared with bipolar coagulation on ovarian reserve after laparoscopic cystectomy for ovarian endometriomas. DESIGN: Patient-blinded, randomised controlled trial. SETTING: University-affiliated tertiary hospital. POPULATION: Women aged 18-40 years with 3-8 cm unilateral or bilateral endometriomas. METHODS: Ninety-four patients were randomised to receive haemostasis by the application of haemostatic sealant (n = 47) or standard care (n = 47). MAIN OUTCOME MEASURES: Primary outcome was the effect on the antral follicular count 3 months after the operation as it captures the effect on the ovary subjected to treatment. Secondary outcomes included the change in anti-Mullerian hormone, follicular-stimulating hormone and peri-operative outcomes including haemostasis, complications, pain, and satisfaction scores. RESULTS: A total of 94 patients aged 32.36 ± 4.92 years underwent laparoscopic cystectomy for ovarian endometriomas. The average diameter of the endometrioma was 4.21 ± 1.38 cm. The increase in antral follicle count of the affected ovaries at 3 months in the intervention group (+2.36 ± 0.37) was significantly (P = 0.013) higher than that in the control group (+1.08 ± 0.36). Repeated measures analysis of variance revealed significant effect with time (P < 0.001) and of interaction of group × time (P = 0.029) for affected ovary antral follicle count. No significant difference was noted between the two groups with regard to follicular-stimulating hormone, anti-Mullerian hormone, and other secondary outcomes. CONCLUSIONS: Applying haemostatic sealant after laparoscopic cystectomy of ovarian endometriomas produced a greater increase in antral follicle count 3 months after surgery compared with the control group. TWEETABLE ABSTRACT: RCT: Haemostatic sealant in laparoscopic cystectomy of endometriomas increase in the antral follicle count after surgery.

My notes (saved in your browser only)

Condition tags

endometrioma

MeSH descriptors

Cystectomy Electrocoagulation Fertility Preservation Hemostasis Laparoscopy Ovarian Neoplasms Teratoma Tissue Adhesives Adult Female Fertility Preservation Hemostasis Humans Ovarian Neoplasms Ovarian Neoplasms Ovarian Reserve Teratoma Teratoma Tissue Adhesives Treatment Outcome

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (20)

Source provenance

openalex
last seen: 2026-05-13T19:29:48.425044+00:00
pubmed
last seen: 2026-10-08T21:24:24.182414+00:00
License: CC0 · commercial use OK