Difference in expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with persistent ovarian cysts

Maria Rosaria Raspollini, Raspollini MR, Francesca Castiglione, Franca Castiglione, Duccio Rossi Degl’Innocenti, Rossi Degl'Innocenti D, Duccio Rossi Degl'Innocenti, Francesca Garbini, Garbini F, Coccia ME, Maria Elisabetta Coccia, Gian Luigi Taddei, Taddei GL
Fertility and sterility · 2005 · vol. 84(4) , pp. 1049–1052 · doi:10.1016/j.fertnstert.2005.02.058 · PMID:16213873 · W1994817906
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This study investigated the expression levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients diagnosed with persistent ovarian cysts.

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Abstract

Matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-9 expression with real-time quantitative polymerase chain reaction were analyzed in endometriotic and nonendometriotic ovarian cysts. Although MMP-1 was not detected, MMP-9 and MMP-2 were expressed in all of the cysts. In particular, in five of six nonendometriotic cysts (83.3%) MMP-2 expression was higher than in endometriotic cysts. These data may represent new molecular elements helpful in differential diagnosis of endometriotic lesions.

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MeSH descriptors

Gene Expression Regulation, Enzymologic Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Ovarian Cysts Chronic Disease Female Gene Expression Regulation, Enzymologic Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Matrix Metalloproteinase 9 Ovarian Cysts Ovarian Cysts Statistics, Nonparametric

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References (20)

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