Feasibility, acceptability, and exploratory outcomes of a virtual cognitive behavioural therapy‐based group intervention for persistent fatigue in endometriosis: The Managing Fatigue in Endometriosis (MEND) programme

Alexandra Spyrelis, Maria Loades, Rizwana Roomaney
British journal of health psychology · 2025 · vol. 30(3) , pp. e70014 · doi:10.1111/bjhp.70014 · PMID:40790811 · PMC12340180 · W4413108782
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study developed and tested the MEND program, a virtual CBT intervention for endometriosis-related fatigue, finding it feasible and acceptable despite high attrition, with mixed exploratory outcomes.

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Abstract

INTRODUCTION: This study developed and assessed the feasibility, acceptability, and exploratory outcomes of a six-session cognitive behavioural therapy (CBT)-based intervention for endometriosis-related persistent fatigue, called Managing Fatigue in Endometriosis (MEND). METHODS: MEND was developed based on CBT for persistent fatigue and a prior qualitative study among fatigued patients with endometriosis in South Africa. After expert review, it was delivered online by trained counsellors to small groups. A single-arm within-subjects study with 21 participants (mean age 33.1, range 23-43 years) reporting moderate to severe fatigue pre-intervention was conducted. Feasibility, acceptability and patient-reported outcome measures were assessed. RESULTS: A high eligibility rate (n = 43, 83%) and lower enrolment rate (n = 21, 49%) were observed. Session attendance varied (43%-76%), with a 57% (n = 12) completion and 28% (n = 5) drop-out rate, mainly due to countrywide power outages during implementation. Qualitative data indicated that the intervention was acceptable to both participants and interventionists. Although not sufficiently powered to determine effectiveness, the Reliable Change Index indicated a mixed pattern of change-some outcomes showed improvement (18%-55%), while others reflected no change (18%-64%) or deterioration (9%-36%). CONCLUSION: MEND was found to be feasible and acceptable, although attrition was high. A randomized controlled trial is warranted to assess treatment efficacy more definitively.

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Outcome instruments

EHP-30 VAS-pain

Condition tags

endometriosis

MeSH descriptors

Cognitive Behavioral Therapy Cognitive Behavioral Therapy Cognitive Behavioral Therapy Cognitive Behavioral Therapy Cognitive Behavioral Therapy Cognitive Behavioral Therapy Cognitive Behavioral Therapy Cognitive Behavioral Therapy Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Fatigue Fatigue Fatigue Fatigue

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (62)

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