Operative Therapie der Endometriose: radikal und schonend zugleich

In: Der Gynäkologe · 2015 · vol. 48(3) , pp. 228–236 · doi:10.1007/s00129-014-3419-8 · W963199075
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AI-generated summary by claude@2026-06+body, 2026-06-14

This review discusses optimizing endometriosis treatment by considering disease severity and fertility desires, noting the long diagnostic delay and high recurrence rates dependent on management and surgical skill.

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This paper is a narrative review focused on operative management of endometriosis, emphasizing how preoperative diagnostic work-up and surgical planning should determine how radical versus minimally invasive surgery should be, considering both disease severity and the patient’s desire for children. Drawing together reported data, it notes that approximately 50% of operated teenagers and up to 32% of reproductive-age women treated surgically for chronic pelvic pain or dysmenorrhea have endometriosis, and that the interval from nonspecific initial symptoms to diagnosis is about 7 years, partly due to inadequate awareness among first-contact specialties. It summarizes multiple treatment options, including watchful waiting, analgesia, hormonal therapy, surgery, and combined medical-surgical strategies, and states that recurrence rates after treatment range from 5% to more than 60%, depending heavily on holistic management and surgical quality; it also highlights that a causal treatment is not possible because pathogenesis is unclear. This paper is centrally about endometriosis — it reviews how to individualize operative therapy by balancing surgical radicality with minimal invasiveness.

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Abstract

Background Endometriosis is the second most common benign female genital disease after uterine leiomyoma.

Objectives

This review discusses the individual management for each patient which should take into account the severity of the disease and whether the patient desires to have children. Endometriosis is defined as the presence of endometrial glands and stroma outside the internal epithelial lining of the cavity of the uterus. As a consequence, endometriosis can cause a wide range of symptoms, such as chronic pelvic pain, subfertility, dysmenorrhea, deep dyspareunia, cyclical bowel or bladder symptoms (e.g. dyschezia, bloating, constipation, rectal bleeding, diarrhea and hematuria), abnormal menstrual bleeding, chronic fatigue and low back pain.

Results

Approximately 50 % of teenage women and up to 32 % of women of reproductive age operated on for chronic pelvic pain or dysmenorrhea, suffer from endometriosis. The time interval between the first unspecific symptoms and the medical diagnosis of endometriosis is approximately 7 years. This is caused not only by the non-specific nature of the symptoms but also by the frequent lack of awareness on the part of the cooperating disciplines with which the patients have first contact. As the pathogenesis of endometriosis is not clearly understood, a causal treatment is still not possible. Treatment options include watchful waiting, analgesia, hormonal medical therapy, surgical intervention and the combination of medical treatment before and/or after surgery. The treatment should be as radical as necessary and as minimal as possible. The recurrence rate among treated patients lies between 5 % and > 60 % and is very much dependent on the integrated management and surgical skills.

Conclusion

To optimize the individual patient treatment a high degree of interdisciplinary cooperation in the diagnosis and treatment is crucial and should be reserved for appropriate centres especially in the case of deep infiltrating endometriosis. Similar content being viewed by others Literatur Alkatout I, Mettler L, Beteta C et al (2013) Combined surgical and hormone therapy for endometriosis is the most effective treatment: prospective, randomized, controlled trial. J Minim Invasive Gynecol 20:473–481 Alkatout I, Schollmeyer T, Hawaldar NA et al (2012) Principles and safety measures of electrosurgery in laparoscopy. JSLS 16:130–139 Clement PB (2007) The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects. 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Fertil Steril 70:1101–1108 Nezhat C, Hajhosseini B, King LP (2011) Laparoscopic management of bowel endometriosis: predictors of severe disease and recurrence. JSLS 15:431–438 Olive DL, Schwartz LB (1993) Endometriosis. N Engl J Med 328:1759–1769 Possover M (2014) Pathophysiologic explanation for bladder retention in patients after laparoscopic surgery for deeply infiltrating rectovaginal and/or parametric endometriosis. Fertil Steril 101:754–758 Roman H, Vassilieff M, Tuech JJ et al (2013) Postoperative digestive function after radical versus conservative surgical philosophy for deep endometriosis infiltrating the rectum. Fertil Steril 99:1695–1704 Ruffo G, Scopelliti F, Manzoni A et al. (2014) Long-term outcome after laparoscopic bowel resections for deep infiltrating endometriosis: a single-center experience after 900 cases. Biomed Res Int 463058 Soares SR, Martinez-Varea A, Hidalgo-Mora JJ et al (2012) Pharmacologic therapies in endometriosis: a systematic review. Fertil Steril 98:529–555 Vercellini P, Pietropaolo G, De Giorgi O et al (2006) Reproductive performance in infertile women with rectovaginal endometriosis: is surgery worthwhile? Am J Obstet Gynecol 195:1303–1310 Vercellini P, DE Matteis S, Somigliana E et al (2013) Long-term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 92:8–16 Danksagung Die Autoren danken für die Bereitstellung von Abb. 1 Mathias Podlovics (a, b) und Professor Dr. Thilo Wedel (c, d). Einhaltung ethischer Richtlinien Interessenkonflikt, I. Alkatout, I. Meinhold-Heerlein, I. von Leffern und N. Maass gebem an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen der Tieren. Author information Authors and Affiliations Corresponding author Zusatzmaterial online Video 1: Ureterolyse bei tief infiltrierender Endometriose der Sakrouterinligamente (WMV 46KB) Video 2: Partielle Resektion eines die Harnblase infiltrierenden Endometrioseknotens (AVI 26KB) Video 3: End-zu-End Anastomose nach laparoskopischer anteriorer Rektumresektion eines transmural gewachsenen Endometrioseknotens (AVI 22KB) Rights and permissions About this article Cite this article Alkatout, I., Meinhold-Heerlein, I., von Leffern, I. et al. Operative Therapie der Endometriose: radikal und schonend zugleich. Gynäkologe 48, 228–236 (2015). https://doi.org/10.1007/s00129-014-3419-8 Published: Issue date: DOI: https://doi.org/10.1007/s00129-014-3419-8

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