Endometriosis-associated epithelial ovarian cancer is a more complicated disease than we suspected before

Szu-Ting Yang, Yang ST, Szu‐Ting Yang, Chang WH, Wen-Hsun Chang, Na-Rong Lee, Lee NR, Lai WA, Wei-An Lai, Shen SH, Shu-Huei Shen, Wen-Ling Lee, Lee WL, Peng‐Hui Wang, Peng-Hui Wang, Wang PH
Taiwanese journal of obstetrics & gynecology · 2021 · vol. 60(6) , pp. 1112–1115 · doi:10.1016/j.tjog.2021.09.027 · PMID:34794748 · W3211757736
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This report details an unusual case of a mixed mucinous and endometrioid adenocarcinoma arising from the same ovary in a patient with endometriosis, highlighting the need for careful pathological diagnosis of endometriosis-associated epithelial ovarian cancer.

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Abstract

OBJECTIVE: Endometriosis-associated epithelial ovarian cancer (EOC) often includes clear cell carcinoma and endometrioid-type carcinoma. Due to the low incidence of primary mucinous EOC and absence of association between endometriosis and primary mucinous EOC, we present an unusual endometriosis-associated mixed mucinous and endometrioid adenocarcinoma arising from the same ovary. CASE REPORT: A 54-year-old woman had an abdominal palpable mass for months. Medical and surgical history, as well as preoperative surveys was unremarkable, except of presence of a pelvic mass. She underwent an exploration laparotomy, and a 22-cm right ovarian tumor was found. Grossly, right ovarian tumor containing brownish cloudy cystic fluid 2450 ml and an apparent 4 × 4 × 2 cm-sized papillary growth. Microscopically, a confluent glandular and infiltrative pattern presented endometrioid adenocarcinoma, and cells with intracytoplasmic mucin and stratified elongated epithelial cells presented mucinous adenocarcinoma. Surgico-pathological stage was FIGO IIIA due to tumor invading to the peritoneum above the pelvis. Postoperatively, the dose-dense chemotherapy was applied with uneventful outcome. CONCLUSION: This is a rare case, composed with mixed mucinous and endometrioid adenocarcinoma of the same ovary, suggesting that careful pathological diagnosis of endometriosis-associated EOC is needed.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Mucinous Carcinoma, Endometrioid Carcinoma, Ovarian Epithelial Ovarian Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Adenocarcinoma, Mucinous Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Cisplatin Cisplatin

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (21)

Cited by (4)

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