Clear Cell Carcinoma Arising from Endometriosis at the Cesarean Scar Site: A Case Report

Mi Kyung Kong, Hyun Joo Jung, Yeon Hee Kim, Jae‐Hoon Kim, Sunghoon Kim
In: Archives of Clinical and Medical Case Reports · 2019 · vol. 03(06) · doi:10.26502/acmcr.96550126 · W2972507326
article OA: diamond CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report details a woman with clear cell carcinoma arising from endometriosis at a cesarean scar site, despite her ovaries being clear of cancer, offering etiological evidence for endometriosis transitioning to carcinoma.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This case report describes a 50-year-old woman with metastatic clear cell carcinoma who previously had a cesarean section in 1992 and excision of an abdominal wall mass diagnosed as endometriosis in 2003. Using imaging (MRI and PET-CT) and pathology from inguinal lymph node biopsy and abdominal wall excision, the authors found clear cell adenocarcinoma associated with endometriosis at the cesarean scar site, with metastasis in regional lymph nodes while both ovaries were grossly and pathologically free of carcinoma. A limitation is that the report is descriptive and does not establish causality or generalizable treatment efficacy, noting the rarity of scar-related malignant transformation and the lack of a standard strategy. Relevance to endometriosis: this paper is centrally about malignant transformation of endometriosis at a cesarean scar site into clear cell adenocarcinoma, explicitly emphasizing the transition from endometriosis to cancer in an extragonadal location and the associated presence of adenomyosis findings in the uterus.

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Abstract

The association of endometriosis with ovarian cancer has been a rare but well-documented phenomenon since 1925, when Sampson first described clear cell carcinoma arising from endometriosis. Here, we report the case of a woman who underwent staging laparotomy including total abdominal hysterectomy and bilateral salpingo-oophorectomy with the excision of an abdominal wall mass at the site of her cesarean section scar. Although the abdominal wall mass and lymph node was proven to be clear cell carcinoma, the patient’s ovaries were free of carcinoma. This case provides important etiological evidence because it is a clear example of endometriosis that has transitioned to clear cell carcinoma. We report this case for review.

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endometriosis

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