Very low dose danazol in idiopathic thrombocytopenic purpura and its role as an immune modulator

R Mylvaganam, Ravindra Mylvaganam, Yeon S. Ahn, Y S Ahn, R O Garcia, R. Garcia, Chae I. Kim, C I Kim, William J. Harrington, W J Harrington
The American journal of the medical sciences · 1989 · vol. 298(4) , pp. 215–220 · doi:10.1097/00000441-198910000-00002 · PMID:2801758 · W2049456268
Non-randomised trial OA: closed CC0 ⤵ 7 in-corpus citations
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This study investigated the efficacy and immunomodulatory effects of very low-dose danazol in patients with idiopathic thrombocytopenic purpura.

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Abstract

Danazol, an attenuated androgen, has been used successfully at its conventional dose (400-800 mg/day) in the treatment of idiopathic thrombocytopenic purpura (ITP). To minimize side effects, the authors tried a very low dose (50 mg/day) regimen which has not been used in any other disease and observed its efficacy in ITP. Fifteen patients were given this dosage of danazol. Its effects on T-cell subsets, B cells, and blastogenic response to pokeweed mitogen (PWM) and staphylococcus aureus (Staph A) were studied before and during therapy. The percentage of CD3 and the percentage and numbers of CD4 were significantly increased during therapy. Responses to PWM, a T-cell dependent B cell mitogen, were also significantly elevated during therapy. However, no change in the percentage of B (CD19) lymphocytes and response to Staph A, a polyclonal B cell mitogen, were noted. There were seven excellent-good and eight fair-poor responses in platelet counts. The excellent-good responders were found to have a more stable CD4 subset between before and during therapy compared to the fair-poor responders (p less than 0.05, Fisher's exact test). Very low dose danazol regimen, therefore, produced a significant increase in the CD4 without affecting the B cells. However, the excellent-good responder patients showed no significant increase in the CD4 lymphocytes.

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MeSH descriptors

Danazol Pregnadienes Purpura, Thrombocytopenic Adult Antigens, Surface Antigens, Surface Danazol Danazol Female Flow Cytometry Humans Immunity, Cellular Immunity, Cellular Leukocyte Count Lymphocyte Activation Lymphocyte Activation Male Phenotype Platelet Count Pregnadienes

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