Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol

Eduardo Shahar, Reuven Bergman, Richard N. Bergman, Shimon Pollack
In: International Journal of Dermatology · 1997 · vol. 36(9) , pp. 708–711 · doi:10.1046/j.1365-4362.1997.00105.x · PMID:9352418 · W2051277256
article OA: closed CC0 ⤵ 3 in-corpus citations
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Danazol administered prophylactically for three days around menses effectively prevented recurrent autoimmune progesterone dermatitis eruptions in two patients.

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Abstract

BACKGROUND: Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective. METHODS: We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women. The treatment regimen consisted of 200 mg danazol twice daily, starting 1-2 days before the expected date of each menses and continuing for 3 days thereafter. RESULTS: This treatment regimen proved to be highly effective in preventing the eruptions in these two patients. CONCLUSIONS: Patients with autoimmune progesterone dermatitis may benefit from prophylactic treatment with danazol.

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