Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol

Eduardo Shahar, E Shahar, R Bergman, Reuven Bergman, Richard N. Bergman, Shimon Pollack, S Pollack
International journal of dermatology · 1997 · vol. 36(9) , pp. 708–711 · doi:10.1046/j.1365-4362.1997.00105.x · PMID:9352418 · W2051277256
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Danazol administered prophylactically for three days around menses effectively prevented recurrent autoimmune progesterone dermatitis eruptions in two patients.

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Abstract

BACKGROUND: Autoimmune progesterone dermatitis is a rare condition appearing during the perimenstrual period or following progesterone treatment. Various treatment modalities have been suggested, but most have proved to be ineffective. METHODS: We used the anabolic androgen danazol as a preventive treatment for recurrent episodes of autoimmune progesterone dermatitis in two young women. The treatment regimen consisted of 200 mg danazol twice daily, starting 1-2 days before the expected date of each menses and continuing for 3 days thereafter. RESULTS: This treatment regimen proved to be highly effective in preventing the eruptions in these two patients. CONCLUSIONS: Patients with autoimmune progesterone dermatitis may benefit from prophylactic treatment with danazol.

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MeSH descriptors

Autoimmune Diseases Danazol Dermatitis Estrogen Antagonists Progesterone Adult Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Biopsy, Needle Danazol Dermatitis Dermatitis Dermatitis Drug Eruptions Drug Eruptions Drug Eruptions Estrogen Antagonists Female

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