Case of autoimmune progesterone dermatitis presenting as necrotic migratory erythema successfully controlled by danazol
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This paper reports the first case of autoimmune progesterone dermatitis presenting as necrotic migratory erythema, which was effectively managed with danazol treatment.
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Abstract
Autoimmune progesterone dermatitis (APD) is a rare cutaneous disorder with cyclic skin eruptions during the luteal phase of the menstrual cycle. Patients can present with various clinical manifestations, including urticaria and angioedema, erythema multiforme, eczema, fixed drug eruption and centrifugal erythema annulare. In our case, however, the patient's skin lesions mimic necrotic migratory erythema (NME) which is most commonly associated with glucagonoma and rarely with liver disease, inflammatory bowel disease, malnutrition and other tumors. To our knowledge, this is the first case of NME-like APD and is successfully controlled by danazol. This also sheds lights on the etiologic diversity of NME.
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Cites (1)
References (6)
- Autoimmune progesterone dermatitis: effective prophylactic treatment with danazol via openalex
- doi:10.1007/s00404-017-4497-3 via openalex
- doi:10.18176/jiaci.0284 via openalex
- doi:10.1016/0091-6749(87)90033-9 via openalex
- doi:10.3892/etm.2018.7055 via openalex
- W2470476212 via openalex
Source provenance
- openalex
- last seen: 2026-05-11T04:44:05.479960+00:00
- pubmed
- last seen: 2026-10-08T21:26:07.973840+00:00
- unpaywall
- last seen: 2026-10-09T06:36:44.367587+00:00
License: CC0
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