Differential expression of claudins in human endometrium and endometriosis

R Gaetje, Gaetje R, Regine Gaetje, Holtrich U, Uwe Holtrich, Knut Engels, Engels K, Kissler S, Stefan Kissler, Achim Rody, Rody A, Thomas Karn, Manfred Kaufmann, Kaufmann M
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2008 · vol. 24(8) , pp. 442–449 · doi:10.1080/09513590802242694 · PMID:18850381 · W1989400324
Other OA: closed CC0 ⤵ 18 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Researchers analyzed claudin expression in human endometrium and endometriosis, finding reduced claudin-3, -4, and -7 in ectopic endometrium, potentially contributing to cell detachment and invasion.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Membrane proteins of the claudin superfamily are important components of cellular tight and adherens junctions. Although their exact function remains unclear, these proteins may play a role in tissue remodeling, a process which is associated with several diseases including endometriosis. In the present work we analyzed the expression of 13 members of the claudin family in the endometrium and peritoneum by microarray analysis. Real-time polymerase chain reaction and immunohistochemistry in human endometrium and peritoneal endometriotic lesions were performed for validation of the expression of claudin-1, -3, -4, -5 and -7. Diminished expression of claudin-3, -4 and -7 in ectopic endometrium was frequently observed as indicated by all three methods. In contrast to a higher expression of claudin-5 mRNA detected in bulk biopsies of ectopic endometrium, immunohistochemistry revealed no alteration of claudin-5 protein expression in glandular cells of endometriosis samples. The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Profiling Gene Expression Profiling Membrane Proteins Adult Adult Claudin-1 Claudin-1 Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female Gene Expression Regulation Gene Expression Regulation Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (18)

Cited by (18)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:05:50.299847+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK