The role of myometrial needle biopsies in the diagnosis of adenomyosis
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This study investigated the diagnostic utility of myometrial needle biopsies for adenomyosis, evaluating their accuracy and safety in identifying the condition.
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Abstract
ObjectiveTo determine the sensitivity and specificity of myometrial needle biopsies in the diagnosis of adenomyosis uteri in vitro.DesignEight needle biopsies and 8 corresponding myometrial blocks were taken from 27 hysterectomy specimens with adenomyosis and 13 specimens with adenomyosis. Adenomyosis was graded on the basis of the depth of endometrial invasion into the myometrium: grade I, adenomyosis within the inner third of the myometrium; grade II, limited to the inner two thirds; and grade III, endometrial penetration into the outer one third of the myometrium. The sensitivity of 4 and 2 biopsies was calculated by conventional probability theory.ResultsTaking 8 needle biopsies from each uterus yielded sensitivities for grade I, II, and III adenomyosis of 9%, 64%, and 100% respectively, but the calculated sensitivities of two biopsies, taken at random, were only 2.3%, 20%, and 56%, respectively. There were no false-positive biopsies.ConclusionsMyometrial needle biopsy is a highly specific technique for the diagnosis of adenomyosis uteri but the sensitivity is low and dependent on the number of biopsies and the depth of adenomyosis.
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Cited by (30)
- Endometriosis 2021
- Herausforderung Adenomyose – operative, endokrine und reproduktionsmedizinische Therapieoptionen 2020
- A Systematic Review of Tissue Sampling Techniques for the Diagnosis of Adenomyosis 2019
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research 2014
- World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research 2014
- Endometriosis 2012
- Adenomyosis: Review of the Literature 2011
- Luteal phase transvaginal scan examinations have better diagnostic potential for showing focal subendometrial adenomyosis 2011
- Adenomiose em pacientes com endometriose profunda: aspectos clínicos, histológicos e radiológicos 2010
- Adenomyosis and ‘endometrial– subendometrial myometrium unit disruption disease’ are two different entities 2008
- Endometriosis 2007
- Laparoscopy-guided myometrial biopsy in the definite diagnosis of diffuse adenomyosis 2007
- Transvaginal ultrasound or MRI for diagnosis of adenomyosis 2007
- Transvaginal ultrasound for diagnosis of adenomyosis: a review 2006
- Therapeutic options for adenomyosis: a review 2006
- New interventional techniques for adenomyosis 2006
- Current diagnostic and treatment strategies for adenomyosis 2006
- Évolutions physiopathologiques, diagnostiques et thérapeutiques dans la prise en charge de l’adénomyose : revue de la littérature 2004
- Adenomyosis 2003
- Transvaginal ultrasound guided biopsies in the diagnosis of pelvic lesions 2003
- Improved Sonographic Accuracy in the Presurgical Diagnosis of Diffuse Adenomyosis 2002
- Adenomyosis and endometrial ablation 2000
- Adenomyosis: Difficult to Diagnose, and Difficult to Treat 2000
- Hysteroscopy and Adenomyosis 2000
- Hysteroscopic myometrial biopsy in unexplained abnormal uterine bleeding 1999
- Surgical and medical treatment of adenomyosis 1998
- Transvaginal ultrasonography versus uterine needle biopsy in the diagnosis of diffuse adenomyosis 1998
- Laparoscopic Diagnosis of Adenomyosis : a Case Report 1997
- Magnetic resonance imaging for diagnosing adenomyomata 1996
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- europepmc
- last seen: 2026-08-09T06:10:49.860119+00:00
- openalex
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- pubmed
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