Danazol and cholestatic hepatitis

Letters and Corrections1 July 1986Danazol and Cholestatic HepatitisBOUE FRANÇOIS, M.D., BENOIT COFFIN, M.D., JEAN-FRANÇOIS DELFRAISSY, M.D.BOUE FRANÇOIS, M.D., BENOIT COFFIN, M.D., JEAN-FRANÇOIS DELFRAISSY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-139_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Danazol, used since 1971 for treatment of pelvic endometriosis, cystic disease of the breast, and hereditary angioneurotic edema, has recently been reported to be effective in idiopathic thrombocytopenic purpura (1). Because danazol is a C17 alkylated anabolic steroid, hepatic dysfunction and jaundice might be expected. We report a case of cholestatic hepatitis apparently induced by danazol.A 73-year-old woman was referred with idiopathic thrombocytopenic purpura responding to prednisone. Treatment was stopped 6 months later with a good result. A moderate relapse occurred 1 year afterwards, and prednisone therapy was restarted. Because of iatrogenic Cushing's syndrome, prednisone was...References1. AHNHARRINGTONSIMONMYLVAGANAMPALLSO YWSRRA. Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med. 1983;308:1396-9. CrossrefMedlineGoogle Scholar2. MADANESFARBER AM. Danazol. Ann Intern Med. 1982;96:625-30. LinkGoogle Scholar3. PEARSONZIMMERMAN KH. Danazol and liver damage. Lancet. 1980;1:645-6. CrossrefMedlineGoogle Scholar4. NESHERDOLLBERGZIMRAN GLA. Hepatosplenic peliosis after danazol and glycocorticoids for ITP. N Engl J Med. 1985;312:242. CrossrefMedlineGoogle Scholar5. BUAMAH P. An apparent danazol-induced primary hepatocellular carcinoma: case report. J Surg Oncol. 1985;28:114-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: HOPITAL ANTOINE BECLERE 92141 Clamart France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs and ToxinsUsing Chemical-Induced Gene Expression in Cultured Human Cells to Predict Chemical ToxicityHepatic injury due to drugs, herbal compounds, chemicals and toxinsDanazolDanazol‐induced hepatocellular carcinomaHepatotoxityDanazol-induced hepatocellular adenoma9 Drug-induced cholestasis 1 July 1986Volume 105, Issue 1Page: 139-140KeywordsEdemaGenetic diseasesHepatitisHepatitis AIdiopathic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 July 1986 PDF downloadLoading ...