Ultrastructural Features of Danazol-Induced Cholestasis: A Case Study

Domenico Alvaro, Claudia Piat, Chiara Francia, Antonio Franchitto, S. Furfaro, Costanzo Valente, L. Capocaccia, Eugenio Gaudio
In: Ultrastructural Pathology · 1996 · vol. 20(5) , pp. 491–495 · doi:10.3109/01913129609016353 · PMID:8883334 · W1981956715
article OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This case study describes ultrastructural changes in a danazol-induced cholestatic syndrome, characterized by dilated bile canaliculi with altered microvilli and dense bile material, despite mild enzyme elevation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A case study of a severe cholestatic syndrome induced by danazol, with ultrastructural description of liver morphology, is reported. Cholestasis appeared after 3 months treatment with danazol (300 mg/daily) and completely resolved 2 months after withdrawal. In spite of the severe increase in serum bilirubin and total serum bile salts, transaminases were only slightly elevated and GGT and alkaline phosphatases were almost normal. Light microscopy shows a pattern of predominantly centrolobular cholestasis without necrosis, with minimal inflammatory infiltrate and with no sign of bile ductule involvement. At the ultrastructural level very dilated bile canaliculus predominate with stunted or loss of microvilli and dense bile material in the lumen. Nonspecific alterations were seen in hepatocyte intracellular organelles. It is suggested that danazol may cause a rare but severe hepatocanalicular cholestasis, differing from the "bland" cholestasis frequently described during therapy with other anabolic steroids.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (1)

Source provenance

openalex
last seen: 2026-05-11T06:28:56.849735+00:00
License: CC0 · commercial use OK