Danazol-induced cholestasis.

M O Silva, Silva MO, K R Reddy, Reddy Kr, T McDonald, Thomas O. McDonald, Jeffers Lj, L J Jeffers, Schiff Er, E R Schiff
The American journal of gastroenterology · 1989 · vol. 84(4) , pp. 426–8 · PMID:2929566 · W2435404419
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case report describes a patient who developed panlobular cholestasis with inflammation after high-dose Danazol treatment, which resolved upon drug discontinuation.

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Abstract

A 39-yr-old female on high-dose Danazol presented with jaundice and pruritus. Danazol-induced cholestasis was suspected, and the drug was discontinued. A liver biopsy revealed panlobular cholestasis with portal and periportal inflammation. The cholestasis resolved completely in 8 wk. This is a rare case of Danazol-induced cholestasis and should be considered in the differential diagnosis of drug-induced liver injury.

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Condition tags

endometriosis

MeSH descriptors

Cholestasis Danazol Pregnadienes Adult Cholestasis Cholestasis Danazol Endometriosis Endometriosis Female Humans Pelvic Neoplasms Pelvic Neoplasms Pregnadienes

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Cited by (5)

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europepmc
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License: CC0 · commercial use OK