Liver Damage Induced by Danazol

Mariano Malaguarnera, I Giugno, G Seminara, Giovanni Biondi, Barbara Adriana Trovato
In: Drug Investigation · 1994 · vol. 8(2) , pp. 122–125 · doi:10.1007/bf03257436 · W146280534
article OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

This paper reviews reported cases of liver damage, including cholestasis, peliosis hepatis, and fulminant hepatic failure, associated with danazol treatment for various conditions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper describes liver damage attributable to danazol, focusing on hepatotoxic outcomes reported after the drug’s use, and places these observations in the context of the existing clinical literature on danazol-associated hepatic injury. The authors discuss reported patterns of injury such as cholestatic hepatitis, jaundice, and rare severe events, drawing on prior case reports and related reviews cited in the manuscript. A key limitation is that the paper’s evidence base is drawn from previously published reports rather than presenting new controlled experimental or prospective cohort data. Relevance to endometriosis: danazol has established use for endometriosis in the cited literature (e.g., “Danazol: A new drug for treatment of endometriosis”), though the paper’s main focus is danazol-induced liver damage rather than studying endometriosis mechanisms or outcomes.

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