Liver Damage Induced by Danazol

Mariano Malaguarnera, I Giugno, G Seminara, Giovanni Biondi, Barbara Adriana Trovato
In: Drug Investigation · 1994 · vol. 8(2) , pp. 122–125 · doi:10.1007/bf03257436 · W146280534
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This paper reports on liver damage occurring in patients treated with danazol.

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This paper describes liver damage attributable to danazol, focusing on hepatotoxic outcomes reported after the drug’s use, and places these observations in the context of the existing clinical literature on danazol-associated hepatic injury. The authors discuss reported patterns of injury such as cholestatic hepatitis, jaundice, and rare severe events, drawing on prior case reports and related reviews cited in the manuscript. A key limitation is that the paper’s evidence base is drawn from previously published reports rather than presenting new controlled experimental or prospective cohort data. Relevance to endometriosis: danazol has established use for endometriosis in the cited literature (e.g., “Danazol: A new drug for treatment of endometriosis”), though the paper’s main focus is danazol-induced liver damage rather than studying endometriosis mechanisms or outcomes.

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Access this article We’re sorry, something doesn't seem to be working properly. Please try refreshing the page. If that doesn't work, please contact support so we can address the problem. References Anonymous. Danazol: A new drug for treatment of endometriosis. Med Lett Drugs Ther 1977; 19: 62-3 Rannevik G. Hormonal, metabolic and clinical effects of danazol in the treatment of endometriosis. Postgr Med J 1979; 5: 14–20 Hosea SW, Santaella ML, Brown EJ, et al. Long term therapy of hereditary angioedema with danazol. Ann Intern Med 1980; 93: 809–12 Dmowski WP. Endocrine properties and clinical application of danazol. Fertil Steril 1979; 31: 237–51 Angello V, Parise RK, Gell J, et al. Preliminary observations on danazol therapy of systemic lupus erythematosus: effects on DNA antibodies thrombocytopenia. J Rheumatol 1983; 10: 682–7 Ahn YS, Harrington WJ, Simons SR, et al. Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med 1983; 308: 1396–9 Fischl MA, Ahn YS, Klimas N, et al. Use of danazol in autoimmune thrombocytopenia associated with acquired immunodeficiency syndrome [abstract]. Blood 1984; 64: 236 Shaw RW. Treatment of endometriosis. Lancet 1992; 340: 1267–71 Pearson K, Zimmerman HJ. Danazol and liver damage. Lancet 1980; 1: 645–6 Boue F, Coffin B, Delfraissy JE Danazol and cholestatic hepatitis. Ann Intern Med 1986; 105(1): 139–40 Silva MO, Reddy KR, McDonald T, et al. Danazol induced cholestasis. Am J Gastroenterol 1989; 84: 426–8 Iwashita S, Ohsawa T. Hepatitis associated with danazol. Drug Intell Clin Pharm 1986; 20: 889 Nesher G, Dollberg L, Zimran A, et al. Hepatosplenic peliosis after danazol and glucocorticoids for ITP. N Engl J Med 1985; 312: 242–3 Bagheri SA, Boyer JL. Peliosis hepatitis associated with androgenic anabolic steroid therapy: a severe form of hepatic injury. Ann Intern Med 1984; 81: 610–8 Nakajima T, Mizushima N, Matsuda H, et al. Fulminant hepatic failure associated with aplastic anaemia after treatment with danazol. Br J Obstet Gynaecol 1986; 93: 1013–5 Xiol X, Martinez-Lacasa J, Pons M, et al. Jaundice after danazol therapy for endometriosis. Am J Gastroenterol 1989; 84(7): 834–5 Sherlock S, Dooley J. Drugs and the liver. In: Sherlock S, Dooley J, editors. Diseases of the liver and biliary system. IX Eds. 23. Oxford: Blackwell Scientific Publications, 1993: 322–56 Kreek MJ, Weser E, Sleisenger MH, et al. Idiopathic cholestasis of pregnancy. The response to challenge with the synthetic estrogen, ethinyl estradiol. N Engl J Med 1967; 277: 1391 Author information Authors and Affiliations Rights and permissions About this article Cite this article Malaguarnera, M., Giugno, I., Seminara, G. et al. Liver Damage Induced by Danazol. Drug Invest 8, 122–125 (1994). https://doi.org/10.1007/BF03257436 Published: Issue date: DOI: https://doi.org/10.1007/BF03257436

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