The American journal of gastroenterology

IntroductionThe incidence of esophagogastric junction adenocarcinoma (EGJAC) has been rising. Intestinal metaplasia of the esophagogastric junction (EGJIM) is a common finding in gastroesophageal reflux (irregular Z-line) and may represent …

Chronic bloating and abdominal distension are common and highly bothersome gastrointestinal symptoms. Although the differential diagnoses for bloating and distension are broad, these symptoms are frequently associated with disorders of the …

Cho, Jonathan J. MD, PhD1; Pak, Kevin MD2; Austin, Ryan P. MD3; Padilla, Leybelis MD2; Wilkerson, Rashad C. DO2; Edson, Theodore D. MD4 Author Information

IntroductionEosinophilic gastritis (EG) is a chronic inflammatory disease of the stomach characterized by eosinophil-predominant gastric mucosal inflammation and gastrointestinal symptoms. The aim of this study was to prospectively evaluate…

Introduction: Endometriosis is a well-known disorder, which most commonly affects women of reproductive age, whereby uterine tissue grows outside of the uterine cavity. Although rare, the most common extra-pelvic location for implantation i…

CASE: Endometriosis, endometrial glands and stroma outside of the uterus, may occur in “extragenital” locations and can present with inflammatory symptoms and/or bowel obstruction similar to inflammatory bowel disease (IBD). We report 2 cas…

IntroductionAbdominal pain is a cardinal feature of irritable bowel syndrome (IBS); however, differences in abdominal pain among IBS subtypes remain unknown. We aimed to characterize abdominal pain symptoms among established IBS subtypes us…

ObjectivesDigestive diseases account for >100 million ambulatory care visits annually in the U.S. Yet, comparatively less is known about the true burden of gastrointestinal (GI) symptoms in the general U.S.PopulationThe aim of this study wa…

Matsushita, Mitsunobu MD; Nishio, Akiyoshi MD; Seki, Toshihito MD; Okazaki, Kazuichi MD Author Information

ObjectivesLinaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of linaclotide in patients with irritable bowel syndrome with constipation (IBS-C).MethodsThis p…

Pelvic floor disorders that affect stool evacuation include structural (for example, rectocele) and functional disorders (for example, dyssynergic defecation (DD)). Meticulous history, digital rectal examination (DRE), and physiological tes…

OBJECTIVES: Intestinal endometriosis (IE) can present with varied symptoms, making the diagnosis difficult. Modalities have been described to evaluate IE, but few can provide a confirmatory diagnosis. A preoperative diagnosis of IE may help…

ObjectivesPsychological and behavioral therapies are being increasingly used for symptom management in patients with irritable bowel syndrome (IBS). The aims of this study were to compare two delivery modes for a comprehensive self-manageme…

ObjectivesCeliac disease (CD) is a chronic inflammatory disease of the small bowel that is characterized by increased intraepithelial lymphocytes (IELs) and villous atrophy of the mucosa. It is unclear how often intraepithelial lymphocytosi…

ObjectiveThere are no endoscopic features that distinguish intestinal metaplasia of the cardia (CIM) from the normal cardia. Biopsy specimens are therefore randomly obtained from normal-appearing mucosa with significant potential sampling e…

Endoscopic appendectomy in a case of appendicular intussusception due to endometriosis, mimicking a cecal polyp

There has been a recent increase in abstracts and publications reporting intestinal metaplasia in the distal esophagus and cardia. The terms "short segment Barrett's esophagus," "intestinal metaplasia of the esophagogastric junction," and "…

ObjectiveBarrett's esophagus has been associated with adenocarcinoma of the esophagogastric junction and gastric cardia. The purpose of this study was to determine whether patients with Barrett's esophagus have a higher prevalence of intest…

Appendiceal endometriosis is a very uncommon clinical entity. We describe a 33-yr-old white female who presented with painless profuse rectal bleeding. Emergency colonoscopy revealed bleeding from the appendiceal opening. An emergency appen…