Danazol‐induced hepatocellular carcinoma

Christian Confavreux, P. Sève, C. Broussolle, P. Renaudier, C Ducerf
In: QJM: An International Journal of Medicine · 2003 · vol. 96(4) , pp. 317 · doi:10.1093/qjmed/hcg050 · PMID:12651980 · W2152912347
letter OA: bronze CC0 ⤵ 3 in-corpus citations
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This case report describes a 37-year-old female with ITP treated with danazol, a drug known for its hepatological side-effects, who subsequently developed hepatocellular carcinoma.

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Abstract

Sir, Danazol, an inhibitor of pituitary gonadotropin with weak androgenic effects, is currently used in the treatment of endometriosis, hereditary angio‐oedema, systemic lupus erythematosus, and idiopathic thrombocytopenic purpura (ITP). Its hepatological side‐effects have been well documented. These include reversible elevations of serum aminotransferase values,1 cholestatic hepatitis,2 hepatic peliosis3 and hepatocellular adenomas.4 Only a few cases of danazol‐associated hepatocellular carcinoma (HCC) have been described.5–,7 We report a new case. A 37‐year‐old female with ITP refractory to corticotherapy, intravenous immunoglobulins, vincristine and splenectomy, was treated with 600 mg danazol daily in March 1995. Danazol induced a dramatic clinical and biological response, settling thrombocytes counts at 40×109 …

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endometriosis

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