Oral contraceptive pills for endometriosis after conservative surgery: a systematic review and meta-analysis

Lixia Wu, Wu L, Qianyu Wu, Wu Q, Liu Lan, Lan Liu, Liu L
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 29(10) , pp. 883–890 · doi:10.3109/09513590.2013.819085 · PMID:23919282 · W2099386298
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Oral contraceptive pills significantly increased endometriosis remission and decreased recurrence rates compared to surgery alone, with fewer mild side effects than other hormonal treatments.

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Abstract

To assess the effects of oral contraceptive pills (OCPs) for endometriosis in women after conservative surgery, we performed a search of PubMed, Embase, ISI Web of Science, Cochrane Library, Scidirect, Chinese VIP, CNKI and WANGFANG database. Randomized controlled trials (RCTs) of OCPs in postoperative medical therapy for endometriosis were collected. Articles published as of January 2013 with no language restriction were identified using defined keywords, and 15 studies comprising 1850 patients were included. There was a significantly higher rate of total endometriosis remission [OR = 2.55, 95% CI (1.68, 3.86), p < 0.00001] and a lower rate of recurrence [OR = 0.31, 95% CI (0.22, 0.45), p < 0.00001] in the OCPs group compared with surgery alone. There appears to be no statistical difference in pregnancy rates between the OCPs group as compared with surgery alone or other hormonal drug treatments in infertility patients. As for the rate of recurrence and complete remission, there were no statistical differences among OCPs and gestrinone, mifepristone or GnRH-a groups. However, OCPs users had less side effects that were more mild as compared with patients using other hormonal treatments.

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Condition tags

endometriosisinfertility

MeSH descriptors

Contraceptives, Oral Endometriosis Endometriosis Gynecologic Surgical Procedures Combined Modality Therapy Contraceptives, Oral Drug Administration Schedule Endometriosis Endometriosis Female Fertility Preservation Fertility Preservation Gynecologic Surgical Procedures Humans Postoperative Period Pregnancy Tablets

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (13)

Cited by (24)

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