Reversible inhibition of spermatogenesis by danazol with combination of testosterone enanthate in rabbit

Nirmal Kumar Lohiya, N K Lohiya, O. P. Sharma
Andrologia · 2009 · vol. 16(1) , pp. 72–75 · doi:10.1111/j.1439-0272.1984.tb00237.x · PMID:6721243 · W1982958776
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Danazol combined with testosterone enanthate caused reversible azoospermia and reduced sperm quality in male rabbits, with full recovery of seminal characteristics after treatment cessation.

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Abstract

Danazol (15 mg/kg b.w./day; oral) with combination of testosterone enanthate (5 mg/kg b.w./15 days; S.C.) was tested in male rabbits for reversible suppression of spermatogenesis. Semen analyses for efficacy and reversibility were performed biweekly. The regimen resulted in complete azoospermia or severe oligozoospermia in all the animals within 75 days of treatment accompanied with decreased motility, vitality and increased sperm abnormalities. Semen volume and pH did not alter significantly. Libido was unaffected. All seminal characteristics were within normal range after 115 days of recovery. In conclusion, the drug combination in given dose regimen resulted in reversible inhibition of spermatogenesis in rabbits.

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MeSH descriptors

Contraceptive Agents, Male Danazol Pregnadienes Spermatogenesis Testosterone Animals Contraceptive Agents, Male Danazol Drug Combinations Male Pregnadienes Rabbits Semen Semen Spermatogenesis Testosterone Testosterone Time Factors

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