N K Lohiya

Danazol (15 mg/kg b.w./day; oral) with combination of testosterone enanthate (5 mg/kg b.w./15 days; S.C.) was tested in male rabbits for reversible suppression of spermatogenesis. Semen analyses for efficacy and reversibility were performed…

Administration of a combination formulation of danazol (100 mg/day; oral) plus testosterone enanthate (TE) (50 mg/15 days; i.m.) for 30 to 60 days in adult male langur monkeys resulted in the reversible suppression of testicular function wi…

Changes in the biochemical composition of semen, which reflect the accessory sex organ functions, following danazol (100 mg/day; orally) plus testosterone enanthate (50 mg/month; i.m.) administration have been investigated in langur monkey.…

Effects of danazol plus testosterone enanthate on rabbit vas deferens are investigated. Seminal, biochemical tissue and histological studies were performed. Sperm motility was markedly impaired with the advancement of treatment. At the end …

A combination of danazol (15 mg/kg b.w./day; oral) plus TE (5 mg/kg b.w./15 days; i.m.) was investigated for reversible inhibition of testicular function in rabbit. Testicular histology and biochemistry were studied before, during (30, 60 &…

Danazol in combination with testosterone enanthate was administered to adult male rabbits to assess the structural and functional activity of epididymis. Seminal, biochemical and histological studies were made throughout the experiment. Spe…

The effects of Danazol on the reproductive organs of female rats have been investigated. Danazol brings about suppression of ovarian weight and distinct follicular atresia indicating antigonadotropic properties. Increase in uterine weight a…

Antifertility and estrogenic effects of Danazol have been studied in female gerbils. Danazol brings about supression of ovarian weight, presumably by inhibiting gonadotrophin secretion. Enlargement of uterine horns and well defined vaginal …

Antifertility and oestrogenic effects of Danazol have been studied in female mice. Danazol brings about suppression of ovarian weight, presumably by inhibiting gonadotropin secretion. Enlargement of uterine horns and well defined vaginal ke…

The effects of chemical sterilization with a single injection of Danazol a synthetic (23-isoxazol) derivative of 17-alpah-ethinyl testosterone into the right testis of male dogs were studied. Disorganization of the seminiferous epithelium a…

Danazol administration caused lesions in the seminiferous tubules of gerbils and mice. The seminiferous epithelium became systematically depleted of spermatogonia, spermatocytes, spermatids, and finally spermatozoa. Danazol administration d…

Danazol caused leukolysis in adult female gerbils. It brings about suppression of ovarian weight, presumably by inhibiting gonadotrophin secretion from the pituitary gland. Uterotrophic action of Danazol is confirmed in ovariectomized anima…

The properties of a new synthetic steroid 17-alpha-pregn-4-en-20-yno-(23-d)isoxazol-17-ol (danazol) were investigated in ovariectomized mice and compared with estrogen-treated spayed mice. Danazol alone or in combination with estradiol dipr…