The effects of Danazol on the female genital tract of the rat

Lohiya NK, N K Lohiya, M Arya
Endokrinologie · 1981 · vol. 78(1) , pp. 41–6 · PMID:7318777 · W2416883935
Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation
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Danazol was found to suppress ovarian weight and cause follicular atresia, while also increasing uterine weight and vaginal keratinization in ovariectomized rats, suggesting estrogenic activity.

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Abstract

The effects of Danazol on the reproductive organs of female rats have been investigated. Danazol brings about suppression of ovarian weight and distinct follicular atresia indicating antigonadotropic properties. Increase in uterine weight and well defined vaginal keratinization was seen in Danazol treated ovariectomized animals. The results were similar to that of oestradiol dipropionate confirming the oestrogenic activity of Danazol.

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MeSH descriptors

Danazol Ovary Pregnadienes Uterus Vagina Animals Castration Danazol Female Organ Size Organ Size Ovary Ovary Pregnadienes Rats Uterus Vagina Vagina

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License: CC0 · commercial use OK