Observations on the effects of 17-α-pregn-4-en-20-yno-(2,3-d) isoxazol-17-ol (Danazol) on the female reproductive tract and pituitary gonadotrophs of gerbil (Meriones hurrianae)
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Danazol suppressed ovarian weight, inhibited gonadotropin secretion, displayed anti-estrogenic effects on the uterus, and induced castration-like changes in the pituitary of female gerbils.
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Abstract
Danazol caused leukolysis in adult female gerbils. It brings about suppression of ovarian weight, presumably by inhibiting gonadotrophin secretion from the pituitary gland. Uterotrophic action of Danazol is confirmed in ovariectomized animals. Danazol counteracted the uterotrophic effect of an exogenous oestrogen. Vaginal smears of Danazol-treated animals retained a dioestrous leukocytic pattern indicating the absence of follicular activity. Decreased RNA synthesis in the uterus indicates the possibility that Danazol is anti-oestrogenic. Castration-like changes were noticed in the anterior lobe of the hypophysis after Danazol administration.
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