Observations on the effects of danazol on the female reproductive tract of mice.
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Danazol suppressed ovarian weight in female mice, likely by inhibiting gonadotropin secretion, and induced uterine horn enlargement and vaginal keratinization in ovariectomized animals, similar to estradiol dipropionate.
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Abstract
Antifertility and oestrogenic effects of Danazol have been studied in female mice. Danazol brings about suppression of ovarian weight, presumably by inhibiting gonadotropin secretion. Enlargement of uterine horns and well defined vaginal keratinization was seen in Danazol treated ovariectomized animals. The results were similar to that of oestradiol dipropionate confirming the estrogenic activity of Danazol.
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- openalex
- last seen: 2026-05-10T10:49:45.548917+00:00
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