Endometriose und Malignom

U Ulrich, O Richter, Eva Wardelmann, E Wardelmann, M Valter, Marcus Valter, R Schmutzler, Martin Sillem, M Sillem, M Possover, Marc Possover, Peter Mallmann, P Mallmann
Zentralblatt fur Gynakologie · 2003 · vol. 125(07/08) , pp. 239–242 · doi:10.1055/s-2003-42277 · PMID:14505256 · W105288580
review OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Malignant tumors rarely arise from endometriosis, primarily affecting the ovary and extragonadal sites like the rectosigmoid, with treatment involving resection and potentially radiotherapy or progestin therapy.

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Abstract

Malignant tumors arising from endometriosis are rare. A frequency of about 1% has been reported with in 80% the ovary, and in 20% extragonadal sites being affected. The most common extragonadal manifestations are the rectosigmoid and the rectovaginal septum. For extragonadal malignant tumors arising from endometriosis, complete resection followed by post-operative radiotherapy, possibly plus adjuvant progestin therapy, is the treatment of choice. Endometriosis-associated ovarian carcinomas are likely to present with lower stage disease and predominantly lower grade tumors. While their treatment follows that of common ovarian cancer, a poorer response to chemotherapy must be considered. As unopposed estrogen replacement therapy has been identified as a risk factor for the development of endometriosis-associated cancer, it is not recommended for hormone replacement therapy in women with a history of endometriosis. Loss of heterozygosity and mutations of the PTEN tumor suppressor gene may be early events of tumorigenesis. Endometriosis and its malignant transformation, perhaps, may serve as a suitable model in this regard. According to recent studies, endometriosis is associated with an increased relative risk of non-Hodgkin lymphoma.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Endometriosis Female Humans Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Rectal Neoplasms Rectal Neoplasms Rectal Neoplasms Vaginal Neoplasms Vaginal Neoplasms Vaginal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (13)

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