Effect of acetylsalicylic acid, paracetamol and placebo on pain and blood loss in dysmenorrheic women

T Janbu, Torun Janbu, P Løkken, B I Nesheim, Britt‐Ingjerd Nesheim
Acta obstetricia et gynecologica Scandinavica. Supplement · 1979 · vol. 58(S87) , pp. 81–85 · doi:10.3109/00016347909157796 · PMID:380253 · W1977243900
Non-randomised trial OA: closed CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study found no significant difference in pain relief or blood loss between acetylsalicylic acid, paracetamol, and placebo in women with dysmenorrhea.

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Abstract

The analgesic effect of paracetamol, acetyl-salicylic acid, and placebo on dysmenorrhea were compared in a double-blind cross-over study of 30 women. There was a moderate placebo effect, but no significant difference was found between the three treatments. Blood loss was also measured and it did not vary, with the type of drug ingested. It is concluded that paracetamol and acetylsalicylic acid in the doses used (0.5 g x 4 for 3 days) were not effective against heavy dysmenorrhea, and that none of the drugs influenced the amount of blood lost.

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Condition tags

dysmenorrhea

MeSH descriptors

Acetaminophen Aspirin Dysmenorrhea Acetaminophen Acetaminophen Adult Aspirin Aspirin Blood Specimen Collection Blood Volume Clinical Trials as Topic Double-Blind Method Drug Evaluation Dysmenorrhea Female Humans Menstruation Placebos

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References (24)

Cited by (5)

SciLite annotations

chemicals 7
acetylsalicylic acid paracetamol paracetamol sulfisoxazole acetyl salicylic acid paracetamol acetylsalicylic acid
organisms 2
noordeloos 2009062 noordeloos 2009062

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License: CC0 · commercial use OK