Aromatase inhibitor (anastrozole) affects growth of endometrioma cells in culture

Shawky Z A Badawy, Badawy Sz, Shereene J. Brown, Shereene Brown, Brown S, Lydia Kaufman, Kaufman L, Wojtowycz MA, Martha A Wojtowycz, Martha Wojtowycz
European journal of obstetrics, gynecology, and reproductive biology · 2015 · vol. 188 , pp. 45–50 · doi:10.1016/j.ejogrb.2015.01.009 · PMID:25839436 · W2063752897
Lab / animal OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated the effect of anastrozole on endometrioma cell growth in culture and observed an impact on their proliferation.

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Abstract

OBJECTIVE: To study the effects of aromatase inhibitor (anastrozole) on the growth and estradiol secretion of endometrioma cells in culture. DESIGN: Endometrioma cells are grown in vitro until maximum growth before used in this study. This was done in the research laboratory for tissue culture, in an academic hospital. INTERVENTIONS: Testosterone at a concentration of 10 μg/mL was added as a substrate for the intracellular aromatase. In addition, aromatase inhibitor was added at a concentration of 200 and 300 μg/mL. The effect on cell growth and estradiol secretion is evaluated using Student's t-test. RESULTS: The use of testosterone increased estradiol secretion by endometrioma cells in culture. The use of aromatase inhibitor significantly inhibited the growth of endometrioma cells, and estradiol secretion. CONCLUSION: Aromatase inhibitor (anastrozole) may be an effective treatment for endometriosis due to inhibition of cellular aromatase.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Aromatase Inhibitors Cell Proliferation Endometriosis Estradiol Nitriles Triazoles Anastrozole Anastrozole Aromatase Inhibitors Aromatase Inhibitors Cell Proliferation Cell Proliferation Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Estradiol Estradiol Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (34)

Cited by (11)

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