Aromatase inhibitor (anastrozole) affects growth of endometrioma cells in culture

Shawky Z A Badawy, Badawy Sz, Shereene J. Brown, Shereene Brown, Brown S, Lydia Kaufman, Kaufman L, Wojtowycz MA, Martha A Wojtowycz, Martha Wojtowycz
European journal of obstetrics, gynecology, and reproductive biology · 2015 · vol. 188 , pp. 45–50 · doi:10.1016/j.ejogrb.2015.01.009 · PMID:25839436 · W2063752897
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the effect of anastrozole on endometrioma cell growth in culture and observed an impact on their proliferation.

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Abstract

ObjectiveTo study the effects of aromatase inhibitor (anastrozole) on the growth and estradiol secretion of endometrioma cells in culture.DesignEndometrioma cells are grown in vitro until maximum growth before used in this study. This was done in the research laboratory for tissue culture, in an academic hospital.InterventionsTestosterone at a concentration of 10 μg/mL was added as a substrate for the intracellular aromatase. In addition, aromatase inhibitor was added at a concentration of 200 and 300 μg/mL. The effect on cell growth and estradiol secretion is evaluated using Student's t-test.ResultsThe use of testosterone increased estradiol secretion by endometrioma cells in culture. The use of aromatase inhibitor significantly inhibited the growth of endometrioma cells, and estradiol secretion.ConclusionAromatase inhibitor (anastrozole) may be an effective treatment for endometriosis due to inhibition of cellular aromatase.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Aromatase Inhibitors Cell Proliferation Endometriosis Estradiol Nitriles Triazoles Anastrozole Aromatase Inhibitors Cell Proliferation Cells, Cultured Endometriosis Endometriosis Estradiol Female Humans Nitriles Testosterone Testosterone Triazoles

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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