A randomized, double-blind crossover trial of sertraline in women with chronic pelvic pain

C C Engel, Charles C. Engel, E A Walker, Edward A. Walker, A L Engel, Angela L. Engel, John Bullis, J Bullis, A Armstrong, Alicia Armstrong
Journal of Psychosomatic Research · 1998 · vol. 44(2) , pp. 203–207 · doi:10.1016/s0022-3999(97)00215-8 · PMID:9532549 · W2007020494
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This randomized, double-blind crossover trial evaluated the efficacy of sertraline in managing chronic pelvic pain in women.

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Abstract

The efficacy of antidepressants as analgesics for a range of chronic pain problems is well documented. However, a controlled trial of an antidepressant for women with chronic pelvic pain has not yet been published. We randomized 23 women from a general gynecology clinic to either double-blind sertraline or placebo. Measures of psychological function, pain, and functional disability were taken at baseline and 6 weeks. After a 2-week washout, the groups were crossed-over and the same measures were done over the next 6 weeks. There were no significant improvements in pain or functional disability noted on sertraline compared to placebo. Studies involving larger samples of patients are needed to confirm these findings.

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Condition tags

chronic_pelvic_pain

MeSH descriptors

1-Naphthylamine Pelvic Pain Selective Serotonin Reuptake Inhibitors 1-Naphthylamine 1-Naphthylamine Adult Chronic Disease Cross-Over Studies Depressive Disorder Depressive Disorder Double-Blind Method Female Humans Middle Aged Pain Measurement Pelvic Pain Pelvic Pain Selective Serotonin Reuptake Inhibitors Sertraline

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References (15)

Cited by (32)

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