A randomized, double-blind crossover trial of sertraline in women with chronic pelvic pain
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This randomized, double-blind crossover trial evaluated the efficacy of sertraline in managing chronic pelvic pain in women.
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Abstract
The efficacy of antidepressants as analgesics for a range of chronic pain problems is well documented. However, a controlled trial of an antidepressant for women with chronic pelvic pain has not yet been published. We randomized 23 women from a general gynecology clinic to either double-blind sertraline or placebo. Measures of psychological function, pain, and functional disability were taken at baseline and 6 weeks. After a 2-week washout, the groups were crossed-over and the same measures were done over the next 6 weeks. There were no significant improvements in pain or functional disability noted on sertraline compared to placebo. Studies involving larger samples of patients are needed to confirm these findings.
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- Pharmacological Treatment of Chronic Pelvic Pain 2020
- The Impact of Female Chronic Pelvic Pain Questionnaire (IF-CPPQ) 2019
- Self-administered cognitive behavioural therapy for women with chronic pelvic pain: design and pilot evaluation 2018
- Chronic Pelvic Pain 2018
- Management of Chronic Pelvic Pain 2017
- New Developments in the Pharmacotherapy of Neuropathic Chronic Pelvic Pain 2016
- Interventions for treating chronic pelvic pain in women 2015
- Measures Used to Assess Chronic Pelvic Pain in Randomized Controlled Clinical Trials: A Systematic Review 2015
- ISPOG European Consensus Statement – chronic pelvic pain in women (short version) 2015
- Non-surgical interventions for the management of chronic pelvic pain 2014
- Chronic Pelvic Pain Unrelated to Endometriosis 2012
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- Visceral hyperalgesia in chronic pelvic pain 2009
- PELVIC PAIN 2009
- Predictors of outcome in a cohort of women with chronic pelvic pain – A follow‐up study 2008
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- Treatment of chronic pelvic pain in men and women 2007
- Chronic pelvic pain: Aetiology and therapy 2006
- Management of chronic pelvic pain: evidence from randomised controlled trials 2006
- Abordagem da dor pélvica crônica em mulheres 2006
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- Chronic Pelvic Pain in Women: Evaluation and Management in Primary Care 2005
- Medical management of chronic pelvic pain: the evidence 2004
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