Effects of simvastatin on the proliferation and apoptosis of human endometrial stromal cells from women with endometriosis

Soo-Hyeon Moon, Seong-Eui Lee, Hwi-Gon Kim, Ook-Hwan Choi, Kyu Sup Lee, Yong-Jin Na
In: Korean Journal of Obstetrics and Gynecology · 2010 · vol. 53(2) , pp. 160 · doi:10.5468/kjog.2010.53.2.160 · W2006615359
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Simvastatin inhibited proliferation and induced apoptosis in human endometrial stromal cells from women with endometriosis by altering cell cycle progression and activating caspase-3.

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Abstract

Objective: To evaluate the effects of simvastatin on the proliferation and apoptosis of human endometrial cells from women with endometriosis. Methods: Endometrial tissues were obtained from four women with endometriosis. The endometrial stromal cells isolated from tissue were cultured with 0, 2 and 10 M simvastatin treatments for 48 hours. The proliferation of endometrial stromal cells was inhibited with 2 and 10 M simvastatin treatments compared to control. The effect of simvastatin on the sub-G1 phase of cell cycle was determined by flow cytometry. The expression of apoptosis related molecule (Bcl-2, Bax and caspase-3) was examined in control and simvastatin treatments using western blot. Results: The sub-G1 phase was higher in 10 M simvastatin than in control and 2 M simvastatin (P<0.05). This result showed that simvastatin could induce apoptosis of stromal cells. The expression of Bcl-2 was increased in simvastatin treatments slightly (P<0.05) and the expression of Bax was not different between control and experimental groups. The activation of caspase-3 was significantly higher in 10 M simvastatin treated group than control and 2 M simvastatin treated groups (P<0.05). Conclusion: Simvastatin induces apoptosis of endometrial stromal cells and inhibits their proliferation. It was considered that simvastatin could potentially be a therapeutic agent for the treatment of endometriosis.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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