Induction of a local pseudo-pregnancy for the treatment of endometriosis

Yuan P, Peng Yuan, Yanhong Huang, Huang Y, Cheng B, Biliang Cheng, Zhang J, Jianfang Zhang, Xin X, Xiaoyan Xin
Medical hypotheses · 2009 · vol. 74(1) , pp. 56–58 · doi:10.1016/j.mehy.2009.08.001 · PMID:19699590 · W2071333951
Other OA: closed CC0 ⤵ 5 in-corpus citations
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This study investigated the induction of a local pseudo-pregnancy state as a potential treatment strategy for endometriosis.

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Abstract

As a common cause of chronic pelvic pain, endometriosis affects 10% of women of reproductive age. The most popular strategy for treating endometriosis is pseudo-pregnancy therapy. However, the efficacy of common systemic pseudo-pregnancy therapy is significantly attenuated by poor compliance because of so many side effects. While levonorgestrel-releasing intrauterine systems (LNG-IUS) successfully localize the effect of pseudo-pregnancy to the genital tract in treating endometriosis, it seemed to be insufficient to suppress the ovarian and extragenital endometriosis. We postulate that induction of a local pseudo-pregnancy via progestogen-loaded microsphere in the lesions of endometriosis may provide a more effective treatment with fewer side effects.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Adult Adult Biocompatible Materials Biocompatible Materials Biocompatible Materials Endometriosis Endometriosis Female Female Humans Humans Intrauterine Devices, Medicated Intrauterine Devices, Medicated Levonorgestrel Levonorgestrel Levonorgestrel Microspheres Microspheres Models, Biological

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (5)

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License: CC0 · commercial use OK