Induction of a local pseudo-pregnancy for the treatment of endometriosis

Yuan P, Peng Yuan, Yanhong Huang, Huang Y, Cheng B, Biliang Cheng, Zhang J, Jianfang Zhang, Xin X, Xiaoyan Xin
Medical hypotheses · 2009 · vol. 74(1) , pp. 56–58 · doi:10.1016/j.mehy.2009.08.001 · PMID:19699590 · W2071333951
article OA: closed CC0 ⤵ 5 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This study investigated the induction of a local pseudo-pregnancy state as a potential treatment strategy for endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

As a common cause of chronic pelvic pain, endometriosis affects 10% of women of reproductive age. The most popular strategy for treating endometriosis is pseudo-pregnancy therapy. However, the efficacy of common systemic pseudo-pregnancy therapy is significantly attenuated by poor compliance because of so many side effects. While levonorgestrel-releasing intrauterine systems (LNG-IUS) successfully localize the effect of pseudo-pregnancy to the genital tract in treating endometriosis, it seemed to be insufficient to suppress the ovarian and extragenital endometriosis. We postulate that induction of a local pseudo-pregnancy via progestogen-loaded microsphere in the lesions of endometriosis may provide a more effective treatment with fewer side effects.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Adult Biocompatible Materials Biocompatible Materials Endometriosis Female Humans Intrauterine Devices, Medicated Levonorgestrel Levonorgestrel Microspheres Models, Biological Models, Theoretical Polymers Pseudopregnancy Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

Cited by (5)

Source provenance

europepmc
last seen: 2026-08-14T06:11:53.302379+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:59.677786+00:00
unpaywall
last seen: 2026-08-14T06:25:32.811723+00:00
License: CC0 · commercial use OK