Bone mineral density in women with deep infiltrating endometriosis who have undergone early bilateral oophorectomy

A. Gosset, Anna Gosset, Gosset A, Escanes C, Claire Escanes, Jean-Michel Pouilles, Pouilles JM, J. M. Pouillès, Fabien Vidal, Vidal F, Yann Tanguy Le Gac, Tanguy Le Gac Y, Plu-Bureau G, Geneviève Plu‐Bureau, Geneviève Plu-Bureau, Florence Trémollières, Trémollieres FA, Florence A Trémollieres
Menopause (New York, N.Y.) · 2020 · vol. 28(3) , pp. 300–306 · doi:10.1097/gme.0000000000001696 · PMID:33177413 · W3098948113
Observational OA: closed CC0 ⤵ 2 in-corpus citations
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Women with deep infiltrating endometriosis who underwent early bilateral oophorectomy had significantly higher lumbar spine and femoral neck bone mineral density compared to controls.

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Abstract

OBJECTIVE: To study bone mineral density (BMD) in women with and without pelvic deep infiltrating endometriosis (DIE) who underwent early bilateral oophorectomy (BO). METHODS: A case-control study was performed in 83 women who underwent early BO before the age of 45 years, 31 for DIE and 52 for another clinical condition. All the women answered a standardized computer-assisted questionnaire to record their clinical and historical data and were medically examined. Lumbar spine and femoral neck BMDs were measured by dual-energy X-ray absorptiometry after early BO. Simultaneously, serum calcium, intact parathyroid, 25-hydroxyvitamin D, and cross-linked C-telopeptide were also measured. Unadjusted and adjusted odds ratios (with 95% confidence intervals [CI]) for endometriosis were calculated using logistic regression. RESULTS: The mean lumbar spine and femoral neck BMDs were significantly higher in women who underwent early BO for DIE than in those who underwent early BO for another clinical condition. After adjusting for age at BMD measurement, years since menopause, age at menarche and body mass index, odds ratio for endometriosis associated with a 1-SD increase in lumbar spine and femoral neck BMD was 2.59 (95% CI: 1.45-4.62) and 2.16 (95% CI: 1.23-3.81), respectively. CONCLUSION: Higher lumbar spine and femoral neck BMDs are associated with an increase in the likelihood of pelvic DIE in women who underwent early BO. This might be expected to the extent that endometriosis is itself associated with enhanced estrogen status, although further studies are needed to confirm such a hypothesis. These findings suggest that BMD measurement could contribute to the hormonal management of surgical menopause in women with DIE.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Bone Density Bone Density Endometriosis Endometriosis Endometriosis Absorptiometry, Photon Absorptiometry, Photon Case-Control Studies Case-Control Studies Female Female Femur Neck Femur Neck Femur Neck Humans Humans Lumbar Vertebrae Lumbar Vertebrae Lumbar Vertebrae Lumbar Vertebrae

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (40)

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