A case-control epidemiologic study of endometriosis

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This case-control study found that earlier menarche, longer menstruation, dysmenorrhea, energetic physical activity during menstruation, and allergic diathesis were associated with an increased risk of endometriosis, while more pregnancies showed a protective effect.

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Abstract

A case-control study involving 203 cases of pelvic endometriosis seen from 1987-1989, and 406 randomly selected and age-matched community controls was conducted in order to provide information relevant to effective prophylaxis of the disease. The diagnosis was confirmed by pathology from laparotomy and/or laparoscopy. A questionnaire focused on menstrual, marital and reproductive status, professional exposure and physical activities, and the results were analyzed by a conditional logistic regression model. Women characterized by earlier menarche ( or = 8 days) were found to be associated with an elevated incurring risk, and a trend of increasing risk associated with primary dysmenorrhea (RR = 2.1 for mild to moderate and RR = 5.2 for severe dysmenorrhea), energetic physical activity during menstruation (RR = 2.1), and allergic diathesis (RR = 1.8) was seen. An inverse relationship was observed between the number of pregnancies and risk of endometriosis, and the protective effect was most significant when only the number of full-term pregnancies was counted. The risk factors of endometriosis are discussed, and intensive treatment of primary dysmenorrhea and avoidance of strenuous exercise during menstruation are identified as important measures in the prevention of endometriosis.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Endometriosis Adult Adult Case-Control Studies Case-Control Studies China China China Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Epidemiologic Methods Epidemiologic Methods Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (18)

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europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
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