Expression of natural killer cell activity with CD107a on ectopic endometrium in woman with endometriosis compared with non-endometriosis

Hilma Putri Lubis, Dudy Aldiansyah, Hairani Siregar, Riza Rivany, Taroeno Hariadi
In: IOP Conference Series: Earth and Environmental Science · 2018 · vol. 125 , pp. 012189 · doi:10.1088/1755-1315/125/1/012189 · W2791155829
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This case-control study found that natural killer cell activity, marked by CD107a expression, was lower in ectopic endometrial tissue from women with endometriosis compared to normal endometrial tissue.

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Abstract

Some factors have an important role in endometriosis pathogenesis; there is an immune cell that plays an important role in endometrial cells that have reflux. Woman with endometriosis experienced the cellular immune disorder. It is suspected that decrease of NK cell in the peritoneal fluid caused by its qualitative defect with CD107a expression as the best marker. The aim of this study was to compare expression of NK Cell activity with CD107a between awoman with endometriosis and non-endometriosis. A case-control study from March until July 2015 in Haji Adam Malik General Hospital. The case group was ectopic endometrial tissue block paraffin and control group was normal endometrial tissue block paraffin. This study included 23 patients in endometriosis group and control group respectively. A majority proportion of CD107a expression in endometriosis group was +1 (16 patients (69.6%)), while the control group was +3 (9 patients (39.1%)). Expression of NK cell activity with CD107a in patients with endometriosis was lower than the control group (p<0.05). It suggested that cellular immune factors may play a role in the pathogenesis of endometriosis.

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endometriosis

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