Endometriosis: recurrence and retreatment

A. H. Decherney, DeCherney AH
Clinical therapeutics · 1993 · vol. 14(6) , pp. 766–72; discussion 765 · PMID:1286484 · W2438819049
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This paper reviews treatment options and recurrence rates for endometriosis, noting that while hysterectomy with oophorectomy is curative, fertility-preserving options like danazol, progestins, or conservative surgery are often followed by recurrence.

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Abstract

Endometriosis, a condition in which endometrial tissue sheds and becomes attached to extrauterine sites, appears to be a progressive or recurrent disease. Although there are a variety of treatment options, the only cure for endometriosis is total abdominal hysterectomy with bilateral oophorectomy. For women who wish to preserve fertility, however, this is not a desirable choice. Because the symptoms of endometriosis suggest a hormonal relationship, pharmacologic management entails inducing anovulation. A concern of both physicians and patients is recurrence of endometriosis after initial response to therapy. Whether symptoms represent recurrent disease or progression of preexisting implants is still unknown. A repeat course of therapy with danazol, a synthetic androgen, may be tried for retreatment of endometriosis. Another option is the progestins. Conservative surgery (ie, laparoscopy) is also an option, but often must be repeated for pain control; combination pharmacologic/surgical therapy, although in widespread use, is not without disadvantages and requires further investigation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Pelvic Neoplasms Pelvic Neoplasms Pelvic Neoplasms Pelvic Neoplasms Combined Modality Therapy Combined Modality Therapy Danazol Danazol Danazol Drug Therapy, Combination Drug Therapy, Combination Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (21)

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