Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility

Małgorzata Szczepańska, Szczepańska M, Przemyslaw Wirstlein, Wirstlein P, Przemysław Wirstlein, Małgorzata Zawadzka, Ewa Wender-Ożegowska, Wender-Ożegowska E, Paweł P. Jagodziński, Jagodziński PP, Paweł P. Jagodzińśki
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2018 · vol. 34(12) , pp. 1084–1090 · doi:10.1080/09513590.2018.1490403 · PMID:30130982 · W2888581931
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Endometrial TET1 and TET2 expression was reduced in women with endometriosis-associated infertility, while TET3 expression increased from the follicular to luteal phase in these women.

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Abstract

Little is known about the differences in ten-eleven translocation 1, 2, and 3 (TET1-3) expression in the endometrial phases in eutopic endometrium from infertile women with endometriosis (IWE) and fertile women without endometriosis (FW). Using RT-qPCR and western blot analysis, we assessed the TET expression in the mid-follicular and mid-luteal phases in eutopic endometrium from IWE (n = 38) and FW (n = 18). Both IWE and FW underwent laparoscopic and histological examinations for endometriosis. In the mid-luteal eutopic endometrium in IWE, compared to that of FW, we found significantly reduced levels of TET1 transcripts and proteins (p = .001 and p = .003, respectively) at the severity stage of I/II (p = .029 and p = .003, respectively) and transcripts only at the severity stage of III/IV (p = .003). In the mid-follicular eutopic endometrium of IWE, compared to that of FW, there was a statistically significant reduction in TET2 transcript levels at the severity stage of III/IV (p = .037). Compared to the mid-follicular endometrium, we found a statistically significant increase in TET3 transcript levels during the mid-luteal phase in the eutopic endometrium of all IWE (p = .034) and in the severity stage of III/IV (p = .025). We observed a change in the expression levels of TET1-3 in the eutopic endometrium of IWE.

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Condition tags

endometriosisinfertility

MeSH descriptors

Dioxygenases DNA-Binding Proteins Endometriosis Infertility, Female Mixed Function Oxygenases Proto-Oncogene Proteins Case-Control Studies Case-Control Studies Dioxygenases Dioxygenases DNA-Binding Proteins DNA-Binding Proteins Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female

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