The use of GnRH agonists in the treatment of endometriomas with or without drainage

Sertaç Batıoğlu, S Batioglu, Batioglu S, H. Çelikkanat, Celikkanat H, H Celikkanat, Mete Gürol Uğur, Ugur M, M Ugur, Mollamahmutoglu L, Leyla Mollamahmutoğlu, L Mollamahmutoglu, Yesilyurt H, Hüseyin Yeşilyurt, H Yesilyurt, M Kundakci, Meral Kundakçi, Kundakci M
JPMA. The Journal of the Pakistan Medical Association · 1996 · vol. 46(2) , pp. 30–2 · PMID:8683844 · W25576511
RCT OA: closed CC0 ⤵ 12 in-corpus citations
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Combining cyst drainage with postoperative GnRH-agonist suppression achieved 100% reduction in ovarian endometrioma size and 37% complete resolution, superior to GnRH-agonist therapy alone.

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Abstract

To assess the efficacy of GnRH-agonist therapy in the treatment of endometriomas with or without surgical intervention, 26 women with laparoscopically proven endometriomas larger than 3 cm were recruited to the study. Fourteen women with 19 endometriomas (5 bilateral), had drainage of endometrioma at initial laparoscopy. After the procedure, ovarian suppression was done with GnRH-a therapy for 6 months. The second group which consisted of 12 women, had 17 endometriomas. No surgical procedure was performed. They received only GnRH-a therapy for 6 months. On repeat laparoscopy, in the first group, the rates of decrease in ovarian AFS scores of endometriomas and complete resolution were found as 100% and 37% respectively. In the second group the response was only 18% (p < 0.0001). It was concluded that drainage of the cyst (surgical therapy) combined with postoperative GnRH-a suppression is a better treatment modality than the use of GnRH-a (medical therapy) alone for endometriomas.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Laparoscopy Laparoscopy Ovarian Diseases Triptorelin Pamoate Adult Adult Combined Modality Therapy Combined Modality Therapy Drainage Drainage Endometriosis Endometriosis Female Female Humans Humans Ovarian Diseases Ovarian Diseases Triptorelin Pamoate

Citation neighborhood (2-hop)

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References (19)

Cited by (12)

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