Initiation of GnRH agonist treatment on 3-5 days postoperatively in endometriosis patients: a randomized controlled trial

Gong L, Lili Gong, Shaofen Zhang, Zhang S, Yi Han, Han Y, Qiqi Long, Long Q, Zou S, Shien Zou, Yuankui Cao, Cao Y
Journal of clinical pharmacology · 2015 · vol. 55(8) , pp. 848–853 · doi:10.1002/jcph.485 · PMID:25694383 · W2170557204
RCT OA: closed CC0 ⤵ 12 in-corpus citations
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Initiating GnRH agonist treatment 3-5 days postoperatively for endometriosis patients resulted in equivalent efficacy to initiating it during menstruation but with significantly less uterine bleeding in the first cycle.

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Abstract

Seventy patients with stage III or IV endometriosis were randomly assigned to 2 groups after conservative surgery. Group O (n = 35) received 3 cycles of a 28-day gonadotropin-releasing hormone agonist (GnRH-a) treatment (goserelin, 3.6 mg) starting 3-5 days postoperatively. Group M (n = 35) received the same treatment starting on days 1-5 of menstruation. Groups were further subdivided according to add-back treatment. Pre- and posttreated levels of estradiol (E2 ), follicle stimulating hormone (FSH), and luteinizing hormone (LH) and visual analog scale (VAS), Kupperman menopausal index (KMI), and bone mineral density (BMD) scores were recorded. The incidence of uterine bleeding was assessed. In both groups, serum levels of E2 , FSH, and LH and VAS scores decreased significantly after treatment. Spotting was the most frequent bleeding pattern. During cycle 1, the bleeding time in group M was much longer that than that in group O (P =.001), and the bleeding rate in group M was significantly higher than that in group O (P =.024, RR = 1.185). In patients with stage III or IV endometriosis, the efficacy of GnRH-a initiated 3-5 days postoperatively was equivalent to that of GnRH-a initiated on days 1-5 of menstruation. Female patients who initiated GnRH-a treatment 3-5 days postoperatively experienced less uterine bleeding during the first cycle of treatment.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Goserelin Adult Adult Drug Administration Schedule Drug Administration Schedule Endometriosis Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (12)

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